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RNA Recognition and Cleavage by the SARS Coronavirus Endoribonuclease

The emerging disease SARS is caused by a novel coronavirus that encodes several unusual RNA-processing enzymes, including non-structural protein 15 (Nsp15), a hexameric endoribonuclease that preferentially cleaves at uridine residues.1., 2., 3. How Nsp15 recognizes and cleaves RNA is not well unders...

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Detalles Bibliográficos
Autores principales: Bhardwaj, Kanchan, Sun, Jingchuan, Holzenburg, Andreas, Guarino, Linda A., Kao, C. Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118729/
https://www.ncbi.nlm.nih.gov/pubmed/16828802
http://dx.doi.org/10.1016/j.jmb.2006.06.021