Cargando…

Differential co-expression analysis reveals early stage transcriptomic decoupling in alzheimer’s disease

BACKGROUND: Alzheimer’s disease (AD) is one of the leading causes of death in the US and there is no validated drugs to stop, slow or prevent AD. Despite tremendous effort on biomarker discovery, existing findings are mostly individual biomarkers and provide limited insights into the transcriptomic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Upadhyaya, Yurika, Xie, Linhui, Salama, Paul, Cao, Sha, Nho, Kwangsik, Saykin, Andrew J., Yan, Jingwen, Alzheimer’s Disease Neuroimaging Initiative, for the
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118822/ https://www.ncbi.nlm.nih.gov/pubmed/32241275 http://dx.doi.org/10.1186/s12920-020-0689-y

Ejemplares similares

Applications of Neuroimaging to Disease-Modification Trials in Alzheimer’s Disease
por: Fleisher, Adam S., et al.
Publicado: (2009)

Benchmarking machine learning models for late-onset alzheimer’s disease prediction from genomic data
por: De Velasco Oriol, Javier, et al.
Publicado: (2019)

The Combination of Functional and Structural MRI Is a Potential Screening Tool in Alzheimer’s Disease
por: Huang, Chun-Chao, et al.
Publicado: (2018)

Topological Measurements of DWI Tractography for Alzheimer's Disease Detection
por: Amoroso, Nicola, et al.
Publicado: (2017)

Classification of Alzheimer's and MCI Patients from Semantically Parcelled PET Images: A Comparison between AV45 and FDG-PET
por: Nozadi, Seyed Hossein, et al.
Publicado: (2018)

Standardized quality metric system for structural brain magnetic resonance images in multi-center neuroimaging study
por: Osadebey, Michael E., et al.
Publicado: (2018)

Identification of functionally connected multi-omic biomarkers for Alzheimer’s disease using modularity-constrained Lasso
por: Xie, Linhui, et al.
Publicado: (2020)

Structural Brain Imaging Phenotypes of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) Found by Hierarchical Clustering
por: Kärkkäinen, Mikko, et al.
Publicado: (2020)

Protective Factors Modulate the Risk of Beta Amyloid in Alzheimer's Disease
por: Zhou, Bin, et al.
Publicado: (2020)

Structural Neuroimaging in the Detection and Prognosis of Pre-Clinical and Early AD
por: Fennema-Notestine, Christine, et al.
Publicado: (2009)

Comparison of nine tractography algorithms for detecting abnormal structural brain networks in Alzheimer’s disease
por: Zhan, Liang, et al.
Publicado: (2015)

Use of Deep-Learning Genomics to Discriminate Healthy Individuals from Those with Alzheimer's Disease or Mild Cognitive Impairment
por: Li, Lanlan, et al.
Publicado: (2021)

Late-life obesity is a protective factor for prodromal Alzheimer’s disease: a longitudinal study
por: Sun, Zhen, et al.
Publicado: (2020)

Identifying the Alteration Patterns of Brain Functional Connectivity in Progressive Mild Cognitive Impairment Patients: A Longitudinal Whole-Brain Voxel-Wise Degree Analysis
por: Deng, Yanjia, et al.
Publicado: (2016)

Plasma sex hormone-binding globulin predicts neurodegeneration and clinical progression in prodromal Alzheimer's disease
por: Xu, Wei, et al.
Publicado: (2020)

Multimodal MRI-based imputation of the Aβ+ in early mild cognitive impairment
por: Tosun, Duygu, et al.
Publicado: (2014)

Functional Evolving Patterns of Cortical Networks in Progression of Alzheimer's Disease: A Graph-Based Resting-State fMRI Study
por: Li, Wei, et al.
Publicado: (2020)

Metabolically healthy obesity reduces the risk of Alzheimer’s disease in elders: a longitudinal study
por: Ma, Ling-Zhi, et al.
Publicado: (2019)

Tissue-Based MRI Intensity Standardization: Application to Multicentric Datasets
por: Robitaille, Nicolas, et al.
Publicado: (2012)

Frequency Specific Effects of ApoE ε4 Allele on Resting-State Networks in Nondemented Elders
por: Liang, Ying, et al.
Publicado: (2017)

Study of the Influence of Age in (18)F-FDG PET Images Using a Data-Driven Approach and Its Evaluation in Alzheimer's Disease
por: Jiang, Jiehui, et al.
Publicado: (2018)

CSF-Targeted Proteomics Indicate Amyloid-Beta Ratios in Patients with Alzheimer's Dementia Spectrum
por: Behzad, Maryam, et al.
Publicado: (2023)

Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study
por: Swaminathan, Shanker, et al.
Publicado: (2011)

A Comprehensive Investigation of the Potential Role of Lipoproteins and Metabolite Profile as Biomarkers of Alzheimer's Disease Compared to the Known CSF Biomarkers
por: Nasab, Azam Sajjadi, et al.
Publicado: (2023)

Integrative analysis of eQTL and GWAS summary statistics reveals transcriptomic alteration in Alzheimer brains
por: Varathan, Pradeep, et al.
Publicado: (2022)

Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease
por: Yan, Jingwen, et al.
Publicado: (2015)

Fused multi-modal similarity network as prior in guiding brain imaging genetic association
por: He, Bing, et al.
Publicado: (2023)

Deep Learning in Alzheimer's Disease: Diagnostic Classification and Prognostic Prediction Using Neuroimaging Data
por: Jo, Taeho, et al.
Publicado: (2019)

Cloud-Based Brain Magnetic Resonance Image Segmentation and Parcellation System for Individualized Prediction of Cognitive Worsening
por: Sakamoto, Ryo, et al.
Publicado: (2019)

A Real-Time Clinical Decision Support System, for Mild Cognitive Impairment Detection, Based on a Hybrid Neural Architecture
por: Suárez-Araujo, Carmen Paz, et al.
Publicado: (2021)

Deep learning detection of informative features in tau PET for Alzheimer’s disease classification
por: Jo, Taeho, et al.
Publicado: (2020)

Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics
por: Hirschfeld, Lauren Rose, et al.
Publicado: (2022)

Genome-Wide Association Analysis across Endophenotypes in Alzheimer’s Disease: Main Effects and Disease Stage-Specific Interactions
por: Rosewood, Thea J., et al.
Publicado: (2023)

Journey to the other side of the brain: asymmetry in patients with chronic mild or moderate traumatic brain injury
por: Ross, David E, et al.
Publicado: (2023)

From phenotype to genotype: an association study of longitudinal phenotypic markers to Alzheimer's disease relevant SNPs
por: Wang, Hua, et al.
Publicado: (2012)

Gene co-expression changes underlying the functional connectomic alterations in Alzheimer’s disease
por: He, Bing, et al.
Publicado: (2022)

Association of peripheral blood DNA methylation level with Alzheimer’s disease progression
por: Li, Qingqin S., et al.
Publicado: (2021)

Genetic variation affecting exon skipping contributes to brain structural atrophy in Alzheimer’s disease
por: Lee, Younghee, et al.
Publicado: (2018)

Association of the top 20 Alzheimer's disease risk genes with [(18)F]flortaucipir PET
por: Stage, Eddie, et al.
Publicado: (2022)

Identification of exon skipping events associated with Alzheimer’s disease in the human hippocampus
por: Han, Seonggyun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_p48hghas7u2j4d2np14vctcpbg