Cargando…

Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission

BACKGROUND: Many studies have revealed that mucosal healing improves the long-term prognosis of ulcerative colitis. Frequent colonoscopy is difficult because of its invasiveness and cost. Therefore, in diagnosing and treating ulcerative colitis, noninvasive, low-cost methods for predicting mucosal h...

Descripción completa

Detalles Bibliográficos
Autores principales: Wakai, Masaki, Hayashi, Ryohei, Tanaka, Shinji, Naito, Toshikatsu, Kumada, Junko, Nomura, Motonobu, Takigawa, Hidehiko, Oka, Shiro, Ueno, Yoshitaka, Ito, Masanori, Chayama, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118889/
https://www.ncbi.nlm.nih.gov/pubmed/32245401
http://dx.doi.org/10.1186/s12876-020-01229-8
_version_ 1783514657404747776
author Wakai, Masaki
Hayashi, Ryohei
Tanaka, Shinji
Naito, Toshikatsu
Kumada, Junko
Nomura, Motonobu
Takigawa, Hidehiko
Oka, Shiro
Ueno, Yoshitaka
Ito, Masanori
Chayama, Kazuaki
author_facet Wakai, Masaki
Hayashi, Ryohei
Tanaka, Shinji
Naito, Toshikatsu
Kumada, Junko
Nomura, Motonobu
Takigawa, Hidehiko
Oka, Shiro
Ueno, Yoshitaka
Ito, Masanori
Chayama, Kazuaki
author_sort Wakai, Masaki
collection PubMed
description BACKGROUND: Many studies have revealed that mucosal healing improves the long-term prognosis of ulcerative colitis. Frequent colonoscopy is difficult because of its invasiveness and cost. Therefore, in diagnosing and treating ulcerative colitis, noninvasive, low-cost methods for predicting mucosal healing using useful biomarkers are required in the clinical setting. This study aimed to evaluate whether serum amyloid A is a better serum biomarker than C-reactive protein in predicting mucosal healing in ulcerative colitis patients in clinical remission. METHODS: Ulcerative colitis patients whose C-reactive protein and serum amyloid A were measured within 1 month before and after colonoscopy were included in this retrospective study, and the relationship between the C-reactive protein and serum amyloid A values and the mucosal condition was analyzed. Mucosal condition was assessed using the Mayo Endoscopic Score, with score 0 or 1 indicating mucosal healing. RESULTS: A total of 199 colonoscopic examinations were conducted in 108 ulcerative colitis patients who underwent C-reactive protein and serum amyloid A blood tests. In clinical remission patients, serum amyloid A showed a strong correlation with mucosal inflammation compared to C-reactive protein and had excellent sensitivity and specificity rates with significant statistical significance. CONCLUSIONS: Serum amyloid A is a more useful marker compared to C-reactive protein in predicting mucosal inflammation in ulcerative colitis patients in clinical remission.
format Online
Article
Text
id pubmed-7118889
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-71188892020-04-07 Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission Wakai, Masaki Hayashi, Ryohei Tanaka, Shinji Naito, Toshikatsu Kumada, Junko Nomura, Motonobu Takigawa, Hidehiko Oka, Shiro Ueno, Yoshitaka Ito, Masanori Chayama, Kazuaki BMC Gastroenterol Research Article BACKGROUND: Many studies have revealed that mucosal healing improves the long-term prognosis of ulcerative colitis. Frequent colonoscopy is difficult because of its invasiveness and cost. Therefore, in diagnosing and treating ulcerative colitis, noninvasive, low-cost methods for predicting mucosal healing using useful biomarkers are required in the clinical setting. This study aimed to evaluate whether serum amyloid A is a better serum biomarker than C-reactive protein in predicting mucosal healing in ulcerative colitis patients in clinical remission. METHODS: Ulcerative colitis patients whose C-reactive protein and serum amyloid A were measured within 1 month before and after colonoscopy were included in this retrospective study, and the relationship between the C-reactive protein and serum amyloid A values and the mucosal condition was analyzed. Mucosal condition was assessed using the Mayo Endoscopic Score, with score 0 or 1 indicating mucosal healing. RESULTS: A total of 199 colonoscopic examinations were conducted in 108 ulcerative colitis patients who underwent C-reactive protein and serum amyloid A blood tests. In clinical remission patients, serum amyloid A showed a strong correlation with mucosal inflammation compared to C-reactive protein and had excellent sensitivity and specificity rates with significant statistical significance. CONCLUSIONS: Serum amyloid A is a more useful marker compared to C-reactive protein in predicting mucosal inflammation in ulcerative colitis patients in clinical remission. BioMed Central 2020-04-03 /pmc/articles/PMC7118889/ /pubmed/32245401 http://dx.doi.org/10.1186/s12876-020-01229-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Wakai, Masaki
Hayashi, Ryohei
Tanaka, Shinji
Naito, Toshikatsu
Kumada, Junko
Nomura, Motonobu
Takigawa, Hidehiko
Oka, Shiro
Ueno, Yoshitaka
Ito, Masanori
Chayama, Kazuaki
Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission
title Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission
title_full Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission
title_fullStr Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission
title_full_unstemmed Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission
title_short Serum amyloid A is a better predictive biomarker of mucosal healing than C-reactive protein in ulcerative colitis in clinical remission
title_sort serum amyloid a is a better predictive biomarker of mucosal healing than c-reactive protein in ulcerative colitis in clinical remission
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118889/
https://www.ncbi.nlm.nih.gov/pubmed/32245401
http://dx.doi.org/10.1186/s12876-020-01229-8
work_keys_str_mv AT wakaimasaki serumamyloidaisabetterpredictivebiomarkerofmucosalhealingthancreactiveproteininulcerativecolitisinclinicalremission
AT hayashiryohei serumamyloidaisabetterpredictivebiomarkerofmucosalhealingthancreactiveproteininulcerativecolitisinclinicalremission
AT tanakashinji serumamyloidaisabetterpredictivebiomarkerofmucosalhealingthancreactiveproteininulcerativecolitisinclinicalremission
AT naitotoshikatsu serumamyloidaisabetterpredictivebiomarkerofmucosalhealingthancreactiveproteininulcerativecolitisinclinicalremission
AT kumadajunko serumamyloidaisabetterpredictivebiomarkerofmucosalhealingthancreactiveproteininulcerativecolitisinclinicalremission
AT nomuramotonobu serumamyloidaisabetterpredictivebiomarkerofmucosalhealingthancreactiveproteininulcerativecolitisinclinicalremission
AT takigawahidehiko serumamyloidaisabetterpredictivebiomarkerofmucosalhealingthancreactiveproteininulcerativecolitisinclinicalremission
AT okashiro serumamyloidaisabetterpredictivebiomarkerofmucosalhealingthancreactiveproteininulcerativecolitisinclinicalremission
AT uenoyoshitaka serumamyloidaisabetterpredictivebiomarkerofmucosalhealingthancreactiveproteininulcerativecolitisinclinicalremission
AT itomasanori serumamyloidaisabetterpredictivebiomarkerofmucosalhealingthancreactiveproteininulcerativecolitisinclinicalremission
AT chayamakazuaki serumamyloidaisabetterpredictivebiomarkerofmucosalhealingthancreactiveproteininulcerativecolitisinclinicalremission