Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington’s disease pathology

BACKGROUND: Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder that affects cognitive and motor abilities by primarily targeting the striatum and cerebral cortex. HD is caused by a mutation elongating the CAG repeats within the Huntingtin gene, resulting in HTT protein mi...

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Detalles Bibliográficos
Autores principales: Savage, Julie C., St-Pierre, Marie-Kim, Carrier, Micaël, El Hajj, Hassan, Novak, Sammy Weiser, Sanchez, Maria Gabriela, Cicchetti, Francesca, Tremblay, Marie-Ève
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118932/
https://www.ncbi.nlm.nih.gov/pubmed/32241286
http://dx.doi.org/10.1186/s12974-020-01782-9

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