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Modified N95 Mask Delivers High Inspired Oxygen Concentrations While Effectively Filtering Aerosolized Microparticles

STUDY OBJECTIVE: In a pandemic, hypoxic patients will require an effective oxygen (O(2)) delivery mask that protects them from inhaling aerosolized particles produced by others, as well as protecting the health care provider from exposure from the patient. We modified an existing N95 mask to optimiz...

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Autores principales: Mardimae, Alexandra, Slessarev, Marat, Han, Jay, Sasano, Hiroshi, Sasano, Nobuko, Azami, Takafumi, Fedorko, Ludwik, Savage, Tim, Fowler, Rob, Fisher, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Emergency Physicians. Published by Mosby, Inc. 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118976/
https://www.ncbi.nlm.nih.gov/pubmed/16997675
http://dx.doi.org/10.1016/j.annemergmed.2006.06.039
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author Mardimae, Alexandra
Slessarev, Marat
Han, Jay
Sasano, Hiroshi
Sasano, Nobuko
Azami, Takafumi
Fedorko, Ludwik
Savage, Tim
Fowler, Rob
Fisher, Joseph A.
author_facet Mardimae, Alexandra
Slessarev, Marat
Han, Jay
Sasano, Hiroshi
Sasano, Nobuko
Azami, Takafumi
Fedorko, Ludwik
Savage, Tim
Fowler, Rob
Fisher, Joseph A.
author_sort Mardimae, Alexandra
collection PubMed
description STUDY OBJECTIVE: In a pandemic, hypoxic patients will require an effective oxygen (O(2)) delivery mask that protects them from inhaling aerosolized particles produced by others, as well as protecting the health care provider from exposure from the patient. We modified an existing N95 mask to optimize O(2) supplementation while maintaining respiratory isolation. METHODS: An N95 mask was modified to deliver O(2) by inserting a plastic manifold consisting of a 1-way inspiratory valve, an O(2) inlet and a gas reservoir. In a prospective repeated-measures study, we studied 10 healthy volunteers in each of 3 phases, investigating (1) the fractional inspiratory concentrations of O(2) (F(I)O(2)) delivered by the N95 O(2) mask, the Hi-Ox(80) O(2) mask, and the nonrebreathing mask during resting ventilation and hyperventilation, each at 3 O(2) flow rates; (2) the ability of the N95 mask, the N95 O(2) mask, and the nonrebreathing mask to filter microparticles from ambient air; and (3) to contain microparticles generated inside the mask. RESULTS: The F(I)O(2)s (median [range]) delivered by the Hi-Ox(80) O(2) mask, the N95 O(2) mask, and the nonrebreathing mask during resting ventilation, at 8 L/minute O(2) flow, were 0.90 (0.79 to 0.96), 0.68 (0.60 to 0.85), and 0.59 (0.52 to 0.68), respectively. During hyperventilation, the FiO(2)s of all 3 masks were clinically equivalent. The N95 O(2) mask, but not the nonrebreathing mask, provided the same efficiency of filtration of internal and external particles as the original N95, regardless of O(2) flow into the mask. CONCLUSION: An N95 mask can be modified to administer a clinically equivalent FiO(2) to a nonrebreathing mask while maintaining its filtration and isolation capabilities.
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spelling pubmed-71189762020-04-03 Modified N95 Mask Delivers High Inspired Oxygen Concentrations While Effectively Filtering Aerosolized Microparticles Mardimae, Alexandra Slessarev, Marat Han, Jay Sasano, Hiroshi Sasano, Nobuko Azami, Takafumi Fedorko, Ludwik Savage, Tim Fowler, Rob Fisher, Joseph A. Ann Emerg Med Article STUDY OBJECTIVE: In a pandemic, hypoxic patients will require an effective oxygen (O(2)) delivery mask that protects them from inhaling aerosolized particles produced by others, as well as protecting the health care provider from exposure from the patient. We modified an existing N95 mask to optimize O(2) supplementation while maintaining respiratory isolation. METHODS: An N95 mask was modified to deliver O(2) by inserting a plastic manifold consisting of a 1-way inspiratory valve, an O(2) inlet and a gas reservoir. In a prospective repeated-measures study, we studied 10 healthy volunteers in each of 3 phases, investigating (1) the fractional inspiratory concentrations of O(2) (F(I)O(2)) delivered by the N95 O(2) mask, the Hi-Ox(80) O(2) mask, and the nonrebreathing mask during resting ventilation and hyperventilation, each at 3 O(2) flow rates; (2) the ability of the N95 mask, the N95 O(2) mask, and the nonrebreathing mask to filter microparticles from ambient air; and (3) to contain microparticles generated inside the mask. RESULTS: The F(I)O(2)s (median [range]) delivered by the Hi-Ox(80) O(2) mask, the N95 O(2) mask, and the nonrebreathing mask during resting ventilation, at 8 L/minute O(2) flow, were 0.90 (0.79 to 0.96), 0.68 (0.60 to 0.85), and 0.59 (0.52 to 0.68), respectively. During hyperventilation, the FiO(2)s of all 3 masks were clinically equivalent. The N95 O(2) mask, but not the nonrebreathing mask, provided the same efficiency of filtration of internal and external particles as the original N95, regardless of O(2) flow into the mask. CONCLUSION: An N95 mask can be modified to administer a clinically equivalent FiO(2) to a nonrebreathing mask while maintaining its filtration and isolation capabilities. American College of Emergency Physicians. Published by Mosby, Inc. 2006-10 2006-09-22 /pmc/articles/PMC7118976/ /pubmed/16997675 http://dx.doi.org/10.1016/j.annemergmed.2006.06.039 Text en Copyright © 2006 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mardimae, Alexandra
Slessarev, Marat
Han, Jay
Sasano, Hiroshi
Sasano, Nobuko
Azami, Takafumi
Fedorko, Ludwik
Savage, Tim
Fowler, Rob
Fisher, Joseph A.
Modified N95 Mask Delivers High Inspired Oxygen Concentrations While Effectively Filtering Aerosolized Microparticles
title Modified N95 Mask Delivers High Inspired Oxygen Concentrations While Effectively Filtering Aerosolized Microparticles
title_full Modified N95 Mask Delivers High Inspired Oxygen Concentrations While Effectively Filtering Aerosolized Microparticles
title_fullStr Modified N95 Mask Delivers High Inspired Oxygen Concentrations While Effectively Filtering Aerosolized Microparticles
title_full_unstemmed Modified N95 Mask Delivers High Inspired Oxygen Concentrations While Effectively Filtering Aerosolized Microparticles
title_short Modified N95 Mask Delivers High Inspired Oxygen Concentrations While Effectively Filtering Aerosolized Microparticles
title_sort modified n95 mask delivers high inspired oxygen concentrations while effectively filtering aerosolized microparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118976/
https://www.ncbi.nlm.nih.gov/pubmed/16997675
http://dx.doi.org/10.1016/j.annemergmed.2006.06.039
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