Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication

Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-ind...

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Autores principales: Li, Yue-Qing, Li, Ze-Lin, Zhao, Wei-Jie, Wen, Rui-Xing, Meng, Qing-Wei, Zeng, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier SAS. 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119042/
https://www.ncbi.nlm.nih.gov/pubmed/16875760
http://dx.doi.org/10.1016/j.ejmech.2006.03.024
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author Li, Yue-Qing
Li, Ze-Lin
Zhao, Wei-Jie
Wen, Rui-Xing
Meng, Qing-Wei
Zeng, Yi
author_facet Li, Yue-Qing
Li, Ze-Lin
Zhao, Wei-Jie
Wen, Rui-Xing
Meng, Qing-Wei
Zeng, Yi
author_sort Li, Yue-Qing
collection PubMed
description Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 ( ≤ 0.5 mg ml(–1)) and no significant cytotoxic effects were observed in vitro.
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spelling pubmed-71190422020-04-03 Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication Li, Yue-Qing Li, Ze-Lin Zhao, Wei-Jie Wen, Rui-Xing Meng, Qing-Wei Zeng, Yi Eur J Med Chem Article Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 ( ≤ 0.5 mg ml(–1)) and no significant cytotoxic effects were observed in vitro. Elsevier SAS. 2006-09 2006-07-27 /pmc/articles/PMC7119042/ /pubmed/16875760 http://dx.doi.org/10.1016/j.ejmech.2006.03.024 Text en Copyright © 2006 Elsevier SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Yue-Qing
Li, Ze-Lin
Zhao, Wei-Jie
Wen, Rui-Xing
Meng, Qing-Wei
Zeng, Yi
Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication
title Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication
title_full Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication
title_fullStr Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication
title_full_unstemmed Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication
title_short Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication
title_sort synthesis of stilbene derivatives with inhibition of sars coronavirus replication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119042/
https://www.ncbi.nlm.nih.gov/pubmed/16875760
http://dx.doi.org/10.1016/j.ejmech.2006.03.024
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