Synthetic studies towards anti-SARS agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate

AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M(pro)). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoal...

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Detalles Bibliográficos
Autores principales: Chng, Shu-Sin, Hoang, Truong-Giang, Wayne Lee, Wei-Woon, Tham, Mun-Pun, Ling, Hui Yvonne, Loh, Teck-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119068/
https://www.ncbi.nlm.nih.gov/pubmed/32287437
http://dx.doi.org/10.1016/j.tetlet.2004.10.146
Descripción
Sumario:AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M(pro)). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes.

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