Synthetic studies towards anti-SARS agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate

AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M(pro)). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoal...

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Autores principales: Chng, Shu-Sin, Hoang, Truong-Giang, Wayne Lee, Wei-Woon, Tham, Mun-Pun, Ling, Hui Yvonne, Loh, Teck-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119068/
https://www.ncbi.nlm.nih.gov/pubmed/32287437
http://dx.doi.org/10.1016/j.tetlet.2004.10.146
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author Chng, Shu-Sin
Hoang, Truong-Giang
Wayne Lee, Wei-Woon
Tham, Mun-Pun
Ling, Hui Yvonne
Loh, Teck-Peng
author_facet Chng, Shu-Sin
Hoang, Truong-Giang
Wayne Lee, Wei-Woon
Tham, Mun-Pun
Ling, Hui Yvonne
Loh, Teck-Peng
author_sort Chng, Shu-Sin
collection PubMed
description AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M(pro)). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes.
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spelling pubmed-71190682020-04-03 Synthetic studies towards anti-SARS agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate Chng, Shu-Sin Hoang, Truong-Giang Wayne Lee, Wei-Woon Tham, Mun-Pun Ling, Hui Yvonne Loh, Teck-Peng Tetrahedron Lett Article AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M(pro)). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes. Elsevier Ltd. 2004-12-20 2004-11-11 /pmc/articles/PMC7119068/ /pubmed/32287437 http://dx.doi.org/10.1016/j.tetlet.2004.10.146 Text en Copyright © 2004 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Chng, Shu-Sin
Hoang, Truong-Giang
Wayne Lee, Wei-Woon
Tham, Mun-Pun
Ling, Hui Yvonne
Loh, Teck-Peng
Synthetic studies towards anti-SARS agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate
title Synthetic studies towards anti-SARS agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate
title_full Synthetic studies towards anti-SARS agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate
title_fullStr Synthetic studies towards anti-SARS agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate
title_full_unstemmed Synthetic studies towards anti-SARS agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate
title_short Synthetic studies towards anti-SARS agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate
title_sort synthetic studies towards anti-sars agents: application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119068/
https://www.ncbi.nlm.nih.gov/pubmed/32287437
http://dx.doi.org/10.1016/j.tetlet.2004.10.146
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