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Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors

N-Substituted isatin derivatives were prepared from the reaction of isatin and various bromides via two steps. Bioactivity assay results (in vitro tests) demonstrated that some of these compounds are potent and selective inhibitors against SARS coronavirus 3CL protease with IC(50) values ranging fro...

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Detalles Bibliográficos
Autores principales:	Chen, Li-Rung, Wang, Yu-Chin, Lin, Yi Wen, Chou, Shan-Yen, Chen, Shyh-Fong, Liu, Lee Tai, Wu, Ying-Ta, Kuo, Chih-Jung, Chen, Tom Shieh-Shung, Juang, Shin-Hun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119080/ https://www.ncbi.nlm.nih.gov/pubmed/15896959 http://dx.doi.org/10.1016/j.bmcl.2005.04.027

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