Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase

The 5′-cap structure is a distinct feature of eukaryotic mRNAs and is important for RNA stability and protein translation by providing a molecular signature for the distinction of self or non-self mRNA. Eukaryotic viruses generally modify the 5′-end of their RNAs to mimic the cellular mRNA structure...

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Detalles Bibliográficos
Autores principales: Sun, Ying, Wang, Zidao, Tao, Jiali, Wang, Yi, Wu, Andong, Yang, Ziwen, Wang, Kaimei, Shi, Liqiao, Chen, Yu, Guo, Deyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119097/
https://www.ncbi.nlm.nih.gov/pubmed/24530452
http://dx.doi.org/10.1016/j.antiviral.2014.02.002

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