The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment

Despite considering vast majority of the transcribed molecules as merely noise RNA in the last decades, recent advances in the field of molecular biology revealed the mysterious role of long non-coding RNAs (lncRNAs), as a massive part of functional non-protein-coding RNAs. As a crucial lncRNA, HOX...

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Autores principales: Mozdarani, Hossein, Ezzatizadeh, Vahid, Rahbar Parvaneh, Roghayeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119166/
https://www.ncbi.nlm.nih.gov/pubmed/32245498
http://dx.doi.org/10.1186/s12967-020-02320-0
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author Mozdarani, Hossein
Ezzatizadeh, Vahid
Rahbar Parvaneh, Roghayeh
author_facet Mozdarani, Hossein
Ezzatizadeh, Vahid
Rahbar Parvaneh, Roghayeh
author_sort Mozdarani, Hossein
collection PubMed
description Despite considering vast majority of the transcribed molecules as merely noise RNA in the last decades, recent advances in the field of molecular biology revealed the mysterious role of long non-coding RNAs (lncRNAs), as a massive part of functional non-protein-coding RNAs. As a crucial lncRNA, HOX antisense intergenic RNA (HOTAIR) has been shown to participate in different processes of normal cell development. Aberrant overexpression of this lncRNA contributes to breast cancer progression, through different molecular mechanisms. In this review, we briefly discuss the structure of HOTAIR in the context of genome and impact of this lncRNA on normal human development. We subsequently summarize the potential role of HOTAIR overexpression on different processes of breast cancer development. Ultimately, the relationship of this lncRNA with different therapeutic approaches is discussed.
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spelling pubmed-71191662020-04-07 The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment Mozdarani, Hossein Ezzatizadeh, Vahid Rahbar Parvaneh, Roghayeh J Transl Med Review Despite considering vast majority of the transcribed molecules as merely noise RNA in the last decades, recent advances in the field of molecular biology revealed the mysterious role of long non-coding RNAs (lncRNAs), as a massive part of functional non-protein-coding RNAs. As a crucial lncRNA, HOX antisense intergenic RNA (HOTAIR) has been shown to participate in different processes of normal cell development. Aberrant overexpression of this lncRNA contributes to breast cancer progression, through different molecular mechanisms. In this review, we briefly discuss the structure of HOTAIR in the context of genome and impact of this lncRNA on normal human development. We subsequently summarize the potential role of HOTAIR overexpression on different processes of breast cancer development. Ultimately, the relationship of this lncRNA with different therapeutic approaches is discussed. BioMed Central 2020-04-03 /pmc/articles/PMC7119166/ /pubmed/32245498 http://dx.doi.org/10.1186/s12967-020-02320-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Mozdarani, Hossein
Ezzatizadeh, Vahid
Rahbar Parvaneh, Roghayeh
The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment
title The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment
title_full The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment
title_fullStr The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment
title_full_unstemmed The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment
title_short The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment
title_sort emerging role of the long non-coding rna hotair in breast cancer development and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119166/
https://www.ncbi.nlm.nih.gov/pubmed/32245498
http://dx.doi.org/10.1186/s12967-020-02320-0
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