Pathogenic Mechanisms Of Anti‐Endothelial Cell Antibodies (AECA): Their Prevalence And Clinical Relevance

Anti‐endothelial cell antibodies (AECA) represent a heterogeneous family of autoantibodies directed against structural endothelial proteins, as well as antigens adhering to endothelial cells. Although AECA immunoassays still show a high‐interlaboratory variability, several findings suggest a pathoge...

Descripción completa

Detalles Bibliográficos
Autores principales: Alessandri, Cristiano, Bombardieri, Michele, Valesini, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2006
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119199/
https://www.ncbi.nlm.nih.gov/pubmed/17131630
http://dx.doi.org/10.1016/S0065-2423(06)42008-4
_version_ 1783514727817674752
author Alessandri, Cristiano
Bombardieri, Michele
Valesini, Guido
author_facet Alessandri, Cristiano
Bombardieri, Michele
Valesini, Guido
author_sort Alessandri, Cristiano
collection PubMed
description Anti‐endothelial cell antibodies (AECA) represent a heterogeneous family of autoantibodies directed against structural endothelial proteins, as well as antigens adhering to endothelial cells. Although AECA immunoassays still show a high‐interlaboratory variability, several findings suggest a pathogenic role of these autoantibodies in diseases characterized by endothelial damage. In this chapter, we analyze the knowledge about AECA prevalence, clinical relevance, and their pathogenic role in autoimmune diseases focusing in particular on systemic lupus erythematosus, antiphospholipid syndrome, systemic sclerosis (SSc), and systemic vasculitis.
format Online
Article
Text
id pubmed-7119199
institution National Center for Biotechnology Information
language English
publishDate 2006
publisher Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-71191992020-04-08 Pathogenic Mechanisms Of Anti‐Endothelial Cell Antibodies (AECA): Their Prevalence And Clinical Relevance Alessandri, Cristiano Bombardieri, Michele Valesini, Guido Adv Clin Chem Article Anti‐endothelial cell antibodies (AECA) represent a heterogeneous family of autoantibodies directed against structural endothelial proteins, as well as antigens adhering to endothelial cells. Although AECA immunoassays still show a high‐interlaboratory variability, several findings suggest a pathogenic role of these autoantibodies in diseases characterized by endothelial damage. In this chapter, we analyze the knowledge about AECA prevalence, clinical relevance, and their pathogenic role in autoimmune diseases focusing in particular on systemic lupus erythematosus, antiphospholipid syndrome, systemic sclerosis (SSc), and systemic vasculitis. Elsevier Inc. 2006 2006-11-06 /pmc/articles/PMC7119199/ /pubmed/17131630 http://dx.doi.org/10.1016/S0065-2423(06)42008-4 Text en Copyright © 2006 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Alessandri, Cristiano
Bombardieri, Michele
Valesini, Guido
Pathogenic Mechanisms Of Anti‐Endothelial Cell Antibodies (AECA): Their Prevalence And Clinical Relevance
title Pathogenic Mechanisms Of Anti‐Endothelial Cell Antibodies (AECA): Their Prevalence And Clinical Relevance
title_full Pathogenic Mechanisms Of Anti‐Endothelial Cell Antibodies (AECA): Their Prevalence And Clinical Relevance
title_fullStr Pathogenic Mechanisms Of Anti‐Endothelial Cell Antibodies (AECA): Their Prevalence And Clinical Relevance
title_full_unstemmed Pathogenic Mechanisms Of Anti‐Endothelial Cell Antibodies (AECA): Their Prevalence And Clinical Relevance
title_short Pathogenic Mechanisms Of Anti‐Endothelial Cell Antibodies (AECA): Their Prevalence And Clinical Relevance
title_sort pathogenic mechanisms of anti‐endothelial cell antibodies (aeca): their prevalence and clinical relevance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119199/
https://www.ncbi.nlm.nih.gov/pubmed/17131630
http://dx.doi.org/10.1016/S0065-2423(06)42008-4
work_keys_str_mv AT alessandricristiano pathogenicmechanismsofantiendothelialcellantibodiesaecatheirprevalenceandclinicalrelevance
AT bombardierimichele pathogenicmechanismsofantiendothelialcellantibodiesaecatheirprevalenceandclinicalrelevance
AT valesiniguido pathogenicmechanismsofantiendothelialcellantibodiesaecatheirprevalenceandclinicalrelevance

Ejemplares similares