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The gut microbiota, environmental factors, and links to the development of food allergy
Food allergy appears to have its roots in an insufficient exposure to a diverse range of environmental microbiota during early life. Microbial exposure ensures the colonization of the gastrointestinal tract with commensal microbes, which is necessary for the induction of a balanced and tolerogenic i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119288/ https://www.ncbi.nlm.nih.gov/pubmed/32265597 http://dx.doi.org/10.1186/s12948-020-00120-x |
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author | Lee, Khui Hung Song, Yong Wu, Weidong Yu, Kan Zhang, Guicheng |
author_facet | Lee, Khui Hung Song, Yong Wu, Weidong Yu, Kan Zhang, Guicheng |
author_sort | Lee, Khui Hung |
collection | PubMed |
description | Food allergy appears to have its roots in an insufficient exposure to a diverse range of environmental microbiota during early life. Microbial exposure ensures the colonization of the gastrointestinal tract with commensal microbes, which is necessary for the induction of a balanced and tolerogenic immune function. High-throughput sequencing technology has facilitated in-depth studies of the gut microbiota as well as bacterial-derived metabolites. Although the role of the microbiota in allergies is now widely studied, its importance for food allergy was only recently noted. Studies in human cohorts have shown that there is an association of dysbiosis and pathogenesis of food allergy, while studies from animal models have demonstrated the capacity of specific species in the gut microbiota to alter immune response, which may lead to the desensitization of food allergy. This article reviews the role of the gut microbiota in food allergy, and discusses the influence of environmental factors as well as prevention and management strategies relating to such regulatory mechanism. |
format | Online Article Text |
id | pubmed-7119288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71192882020-04-07 The gut microbiota, environmental factors, and links to the development of food allergy Lee, Khui Hung Song, Yong Wu, Weidong Yu, Kan Zhang, Guicheng Clin Mol Allergy Review Food allergy appears to have its roots in an insufficient exposure to a diverse range of environmental microbiota during early life. Microbial exposure ensures the colonization of the gastrointestinal tract with commensal microbes, which is necessary for the induction of a balanced and tolerogenic immune function. High-throughput sequencing technology has facilitated in-depth studies of the gut microbiota as well as bacterial-derived metabolites. Although the role of the microbiota in allergies is now widely studied, its importance for food allergy was only recently noted. Studies in human cohorts have shown that there is an association of dysbiosis and pathogenesis of food allergy, while studies from animal models have demonstrated the capacity of specific species in the gut microbiota to alter immune response, which may lead to the desensitization of food allergy. This article reviews the role of the gut microbiota in food allergy, and discusses the influence of environmental factors as well as prevention and management strategies relating to such regulatory mechanism. BioMed Central 2020-04-02 /pmc/articles/PMC7119288/ /pubmed/32265597 http://dx.doi.org/10.1186/s12948-020-00120-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Lee, Khui Hung Song, Yong Wu, Weidong Yu, Kan Zhang, Guicheng The gut microbiota, environmental factors, and links to the development of food allergy |
title | The gut microbiota, environmental factors, and links to the development of food allergy |
title_full | The gut microbiota, environmental factors, and links to the development of food allergy |
title_fullStr | The gut microbiota, environmental factors, and links to the development of food allergy |
title_full_unstemmed | The gut microbiota, environmental factors, and links to the development of food allergy |
title_short | The gut microbiota, environmental factors, and links to the development of food allergy |
title_sort | gut microbiota, environmental factors, and links to the development of food allergy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119288/ https://www.ncbi.nlm.nih.gov/pubmed/32265597 http://dx.doi.org/10.1186/s12948-020-00120-x |
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