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The relevance of allergen exposure to the development of asthma in childhood()()()
Sensitization to 1 or more of the common indoor allergens has been consistently associated with asthma among children and young adults (odds ratios for asthma, 3-18). For dust mite and cockroach allergens, there is a dose response relationship between domestic exposure and sensitization. Given that...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mosby, Inc.
2000
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119362/ https://www.ncbi.nlm.nih.gov/pubmed/10669532 http://dx.doi.org/10.1016/S0091-6749(00)90051-4 |
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author | Platts-Mills, Thomas A.E. Rakes, Gary Heymann, Peter W. |
author_facet | Platts-Mills, Thomas A.E. Rakes, Gary Heymann, Peter W. |
author_sort | Platts-Mills, Thomas A.E. |
collection | PubMed |
description | Sensitization to 1 or more of the common indoor allergens has been consistently associated with asthma among children and young adults (odds ratios for asthma, 3-18). For dust mite and cockroach allergens, there is a dose response relationship between domestic exposure and sensitization. Given that allergen provocation can induce many of the features of asthma, the findings strongly suggest that there is a causal relationship between allergen exposure in the home and asthma. However, it remains unclear at what time the critical exposure occurs (ie, in infancy or later) and what role allergen exposure has played in the increasing prevalence and severity of asthma. Objective evidence of an immune response to allergens is generally not present until after 2 years of age. Viral infections play several different roles in asthma in childhood. In infancy, respiratory syncytial virus infection can induce bronchiolitis and set up recurrent wheezing over the next few years. However, the risk factors for this are maternal smoking and small lungs at birth, rather than allergy. By contrast, the role of rhinovirus in precipitating attacks in children and young adults is strongly associated with allergy. Thus the likely scenario is that allergen exposure over the first few years of life induces sensitization (ie, T(H2) cells and IgE antibodies). Continuing exposure can maintain inflammation in the nose and lungs. However, many other factors contribute to wheezing such that there is no simple relationship between allergen exposure and asthma. Nonetheless, it is clear that the changes that have increased asthma have acted on allergic children. (J Allergy Clin Immunol 2000;105:S503-8.) |
format | Online Article Text |
id | pubmed-7119362 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2000 |
publisher | Mosby, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71193622020-04-08 The relevance of allergen exposure to the development of asthma in childhood()()() Platts-Mills, Thomas A.E. Rakes, Gary Heymann, Peter W. J Allergy Clin Immunol Article Sensitization to 1 or more of the common indoor allergens has been consistently associated with asthma among children and young adults (odds ratios for asthma, 3-18). For dust mite and cockroach allergens, there is a dose response relationship between domestic exposure and sensitization. Given that allergen provocation can induce many of the features of asthma, the findings strongly suggest that there is a causal relationship between allergen exposure in the home and asthma. However, it remains unclear at what time the critical exposure occurs (ie, in infancy or later) and what role allergen exposure has played in the increasing prevalence and severity of asthma. Objective evidence of an immune response to allergens is generally not present until after 2 years of age. Viral infections play several different roles in asthma in childhood. In infancy, respiratory syncytial virus infection can induce bronchiolitis and set up recurrent wheezing over the next few years. However, the risk factors for this are maternal smoking and small lungs at birth, rather than allergy. By contrast, the role of rhinovirus in precipitating attacks in children and young adults is strongly associated with allergy. Thus the likely scenario is that allergen exposure over the first few years of life induces sensitization (ie, T(H2) cells and IgE antibodies). Continuing exposure can maintain inflammation in the nose and lungs. However, many other factors contribute to wheezing such that there is no simple relationship between allergen exposure and asthma. Nonetheless, it is clear that the changes that have increased asthma have acted on allergic children. (J Allergy Clin Immunol 2000;105:S503-8.) Mosby, Inc. 2000-02 2004-02-23 /pmc/articles/PMC7119362/ /pubmed/10669532 http://dx.doi.org/10.1016/S0091-6749(00)90051-4 Text en Copyright © 2000 Mosby, Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Platts-Mills, Thomas A.E. Rakes, Gary Heymann, Peter W. The relevance of allergen exposure to the development of asthma in childhood()()() |
title | The relevance of allergen exposure to the development of asthma in childhood()()() |
title_full | The relevance of allergen exposure to the development of asthma in childhood()()() |
title_fullStr | The relevance of allergen exposure to the development of asthma in childhood()()() |
title_full_unstemmed | The relevance of allergen exposure to the development of asthma in childhood()()() |
title_short | The relevance of allergen exposure to the development of asthma in childhood()()() |
title_sort | relevance of allergen exposure to the development of asthma in childhood()()() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119362/ https://www.ncbi.nlm.nih.gov/pubmed/10669532 http://dx.doi.org/10.1016/S0091-6749(00)90051-4 |
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