Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP

Myelin basic protein (MBP) appears frequently in the cerebrospinal fluid (CSF) of mice with chronic demyelination following intracerebral infection with Theiler's murine encephalomyelitis virus (TMEV); antibody to MBP can frequently be found in the sera. The peaks of the immune responses to bot...

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Autores principales: Rauch, Helene C., Montgomery, Ilene Nowicki, Hinman, Channing L., Harb, Walid, Benjamins, Joyce A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1987
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119459/
https://www.ncbi.nlm.nih.gov/pubmed/2433306
http://dx.doi.org/10.1016/0165-5728(87)90099-3
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author Rauch, Helene C.
Montgomery, Ilene Nowicki
Hinman, Channing L.
Harb, Walid
Benjamins, Joyce A.
author_facet Rauch, Helene C.
Montgomery, Ilene Nowicki
Hinman, Channing L.
Harb, Walid
Benjamins, Joyce A.
author_sort Rauch, Helene C.
collection PubMed
description Myelin basic protein (MBP) appears frequently in the cerebrospinal fluid (CSF) of mice with chronic demyelination following intracerebral infection with Theiler's murine encephalomyelitis virus (TMEV); antibody to MBP can frequently be found in the sera. The peaks of the immune responses to both MBP and TMEV coincide with the time course of the clinical signs of disease. Adsorption of mouse sera with TMEV or MBP indicate the non-identity of the antigens and the specificity of the antisera as measured by ELISA. Immunoblot analysis of sera confirmed the ELISA findings. The mechanism of induction of antibody directed against MBP and its role in TMEV-associated demyelination remain to be determined.
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spelling pubmed-71194592020-04-08 Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP Rauch, Helene C. Montgomery, Ilene Nowicki Hinman, Channing L. Harb, Walid Benjamins, Joyce A. J Neuroimmunol Article Myelin basic protein (MBP) appears frequently in the cerebrospinal fluid (CSF) of mice with chronic demyelination following intracerebral infection with Theiler's murine encephalomyelitis virus (TMEV); antibody to MBP can frequently be found in the sera. The peaks of the immune responses to both MBP and TMEV coincide with the time course of the clinical signs of disease. Adsorption of mouse sera with TMEV or MBP indicate the non-identity of the antigens and the specificity of the antisera as measured by ELISA. Immunoblot analysis of sera confirmed the ELISA findings. The mechanism of induction of antibody directed against MBP and its role in TMEV-associated demyelination remain to be determined. Published by Elsevier B.V. 1987-02 2002-11-13 /pmc/articles/PMC7119459/ /pubmed/2433306 http://dx.doi.org/10.1016/0165-5728(87)90099-3 Text en Copyright © 1987 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Rauch, Helene C.
Montgomery, Ilene Nowicki
Hinman, Channing L.
Harb, Walid
Benjamins, Joyce A.
Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP
title Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP
title_full Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP
title_fullStr Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP
title_full_unstemmed Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP
title_short Chronic Theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against MBP
title_sort chronic theiler's virus infection in mice: appearance of myelin basic protein in the cerebrospinal fluid and serum antibody directed against mbp
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119459/
https://www.ncbi.nlm.nih.gov/pubmed/2433306
http://dx.doi.org/10.1016/0165-5728(87)90099-3
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