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Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals
Infection of mice with mouse hepatitis virus (MHV) strain A59 results in acute encephalitis, hepatitis, and chronic demyelinating disease. T lymphocytes play an important role in MHV infection, and costimulatory signals are an important component of T cell function. To elucidate the role of the main...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier/North-Holland
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119462/ https://www.ncbi.nlm.nih.gov/pubmed/14698856 http://dx.doi.org/10.1016/j.jneuroim.2003.10.053 |
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author | Gonzales, Donna M Fu, Li Li, Yun Das Sarma, Jayasri Lavi, Ehud |
author_facet | Gonzales, Donna M Fu, Li Li, Yun Das Sarma, Jayasri Lavi, Ehud |
author_sort | Gonzales, Donna M |
collection | PubMed |
description | Infection of mice with mouse hepatitis virus (MHV) strain A59 results in acute encephalitis, hepatitis, and chronic demyelinating disease. T lymphocytes play an important role in MHV infection, and costimulatory signals are an important component of T cell function. To elucidate the role of the main costimulatory molecule, CD28, in MHV pathogenesis and demyelination, we examined the kinetics of MHV-A59 infection in CD28 knockout mice. MHV-A59-infected CD28 knockout mice developed acute encephalitis and hepatitis, and the same degree of chronic demyelination as normal C57Bl/6 (B6) mice. Thus, CD28, the costimulatory T cell molecule, is not required for MHV infection and MHV-induced demyelination. |
format | Online Article Text |
id | pubmed-7119462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | Elsevier/North-Holland |
record_format | MEDLINE/PubMed |
spelling | pubmed-71194622020-04-08 Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals Gonzales, Donna M Fu, Li Li, Yun Das Sarma, Jayasri Lavi, Ehud J Neuroimmunol Article Infection of mice with mouse hepatitis virus (MHV) strain A59 results in acute encephalitis, hepatitis, and chronic demyelinating disease. T lymphocytes play an important role in MHV infection, and costimulatory signals are an important component of T cell function. To elucidate the role of the main costimulatory molecule, CD28, in MHV pathogenesis and demyelination, we examined the kinetics of MHV-A59 infection in CD28 knockout mice. MHV-A59-infected CD28 knockout mice developed acute encephalitis and hepatitis, and the same degree of chronic demyelination as normal C57Bl/6 (B6) mice. Thus, CD28, the costimulatory T cell molecule, is not required for MHV infection and MHV-induced demyelination. Elsevier/North-Holland 2004-01 2003-12-22 /pmc/articles/PMC7119462/ /pubmed/14698856 http://dx.doi.org/10.1016/j.jneuroim.2003.10.053 Text en Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Gonzales, Donna M Fu, Li Li, Yun Das Sarma, Jayasri Lavi, Ehud Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals |
title | Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals |
title_full | Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals |
title_fullStr | Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals |
title_full_unstemmed | Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals |
title_short | Coronavirus-induced demyelination occurs in the absence of CD28 costimulatory signals |
title_sort | coronavirus-induced demyelination occurs in the absence of cd28 costimulatory signals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119462/ https://www.ncbi.nlm.nih.gov/pubmed/14698856 http://dx.doi.org/10.1016/j.jneuroim.2003.10.053 |
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