Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers()

The roles of intracellular second messengers in interferon-γ (IFN-γ)-induced Ia antigen (Ag) expression by astroglia and microglia were examined. Ia Ag on both glia types was induced by IFN-γ. Reagents known to increase intracellular cAMP or activate intracellular protein kinase C (PKC) reduced IFN-...

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Detalles Bibliográficos
Autores principales: Sasaki, Atsushi, Levison, Steven W., Ting, Jenny P.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1990
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119474/
https://www.ncbi.nlm.nih.gov/pubmed/2170439
http://dx.doi.org/10.1016/0165-5728(90)90164-I
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author Sasaki, Atsushi
Levison, Steven W.
Ting, Jenny P.-Y.
author_facet Sasaki, Atsushi
Levison, Steven W.
Ting, Jenny P.-Y.
author_sort Sasaki, Atsushi
collection PubMed
description The roles of intracellular second messengers in interferon-γ (IFN-γ)-induced Ia antigen (Ag) expression by astroglia and microglia were examined. Ia Ag on both glia types was induced by IFN-γ. Reagents known to increase intracellular cAMP or activate intracellular protein kinase C (PKC) reduced IFN-γ-induced Ia Ag expression by astroglia. In contrast, increasing intracellular cAMP had no suppressive effect on Ia Ag expression by microglia. These results indicate (1) cAMP and PKC negatively regulate IFN-γ-induced Ia expression on astroglia, and (2) Ia expression is regulated differentially in astroglia vs. microglia. These findings may explain the frequent observation of Ia(+) microglia (or macrophages) but not astroglia in various neurodegenerative diseases.
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spelling pubmed-71194742020-04-08 Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers() Sasaki, Atsushi Levison, Steven W. Ting, Jenny P.-Y. J Neuroimmunol Article The roles of intracellular second messengers in interferon-γ (IFN-γ)-induced Ia antigen (Ag) expression by astroglia and microglia were examined. Ia Ag on both glia types was induced by IFN-γ. Reagents known to increase intracellular cAMP or activate intracellular protein kinase C (PKC) reduced IFN-γ-induced Ia Ag expression by astroglia. In contrast, increasing intracellular cAMP had no suppressive effect on Ia Ag expression by microglia. These results indicate (1) cAMP and PKC negatively regulate IFN-γ-induced Ia expression on astroglia, and (2) Ia expression is regulated differentially in astroglia vs. microglia. These findings may explain the frequent observation of Ia(+) microglia (or macrophages) but not astroglia in various neurodegenerative diseases. Published by Elsevier B.V. 1990 2002-11-11 /pmc/articles/PMC7119474/ /pubmed/2170439 http://dx.doi.org/10.1016/0165-5728(90)90164-I Text en Copyright © 1990 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Sasaki, Atsushi
Levison, Steven W.
Ting, Jenny P.-Y.
Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers()
title Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers()
title_full Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers()
title_fullStr Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers()
title_full_unstemmed Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers()
title_short Differential suppression of interferon-γ-induced Ia antigen expression on cultured rat astroglia and microglia by second messengers()
title_sort differential suppression of interferon-γ-induced ia antigen expression on cultured rat astroglia and microglia by second messengers()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119474/
https://www.ncbi.nlm.nih.gov/pubmed/2170439
http://dx.doi.org/10.1016/0165-5728(90)90164-I
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