Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model

We have used cell or tissue-specific promoters to express lymphocytic choriomeningitis virus (LCMV) proteins in selected cells in independent lines of transgenic mice. Upon adoptive transfers into these mice, MHC-restricted LCMV-specific cytotoxic T lymphocytes homed specifically to either the choro...

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Detalles Bibliográficos
Autores principales: Oldstone, Michael B.A., Southern, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1993
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119476/
https://www.ncbi.nlm.nih.gov/pubmed/8360331
http://dx.doi.org/10.1016/0165-5728(93)90230-V
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author Oldstone, Michael B.A.
Southern, Peter J.
author_facet Oldstone, Michael B.A.
Southern, Peter J.
author_sort Oldstone, Michael B.A.
collection PubMed
description We have used cell or tissue-specific promoters to express lymphocytic choriomeningitis virus (LCMV) proteins in selected cells in independent lines of transgenic mice. Upon adoptive transfers into these mice, MHC-restricted LCMV-specific cytotoxic T lymphocytes homed specifically to either the choroid plexus (SV40 promoter) or β cells of the islets of Langerhans (rat insulin promoter). The availability of promoters specific for neurons, oligodendrocytes and astrocytes makes this approach compelling for evaluating T cell trafficking into the CNS and for analyzing antigen presentation in vivo in the CNS.
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spelling pubmed-71194762020-04-08 Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model Oldstone, Michael B.A. Southern, Peter J. J Neuroimmunol Article We have used cell or tissue-specific promoters to express lymphocytic choriomeningitis virus (LCMV) proteins in selected cells in independent lines of transgenic mice. Upon adoptive transfers into these mice, MHC-restricted LCMV-specific cytotoxic T lymphocytes homed specifically to either the choroid plexus (SV40 promoter) or β cells of the islets of Langerhans (rat insulin promoter). The availability of promoters specific for neurons, oligodendrocytes and astrocytes makes this approach compelling for evaluating T cell trafficking into the CNS and for analyzing antigen presentation in vivo in the CNS. Published by Elsevier B.V. 1993-07 2002-12-10 /pmc/articles/PMC7119476/ /pubmed/8360331 http://dx.doi.org/10.1016/0165-5728(93)90230-V Text en Copyright © 1993 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Oldstone, Michael B.A.
Southern, Peter J.
Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model
title Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model
title_full Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model
title_fullStr Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model
title_full_unstemmed Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model
title_short Trafficking of activated cytotoxic T lymphocytes into the central nervous system: Use of a transgenic model
title_sort trafficking of activated cytotoxic t lymphocytes into the central nervous system: use of a transgenic model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119476/
https://www.ncbi.nlm.nih.gov/pubmed/8360331
http://dx.doi.org/10.1016/0165-5728(93)90230-V
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