Oral treatment of transmissible gastroenteritis with natural human interferon alpha: A field study

During a natural outbreak of transmissible gastroenteritis (TGE), groups of piglets were treated orally for 4 consecutive days with placebo or 1.0, 10.0 or 20.0 international units (IU) natural human interferon alpha (nHuIFNα). Piglets that were 1–12 days of age and given 1.0, 10.0 or 20.0 IU nHuIFN...

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Detalles Bibliográficos
Autores principales: Cummins, Joseph M., Mock, Richard E., Shive, Bradford W., Krakowka, Steven, Richards, Alan B., Hutcheson, David P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1995
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119574/
https://www.ncbi.nlm.nih.gov/pubmed/7676616
http://dx.doi.org/10.1016/0165-2427(94)05351-R
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author Cummins, Joseph M.
Mock, Richard E.
Shive, Bradford W.
Krakowka, Steven
Richards, Alan B.
Hutcheson, David P.
author_facet Cummins, Joseph M.
Mock, Richard E.
Shive, Bradford W.
Krakowka, Steven
Richards, Alan B.
Hutcheson, David P.
author_sort Cummins, Joseph M.
collection PubMed
description During a natural outbreak of transmissible gastroenteritis (TGE), groups of piglets were treated orally for 4 consecutive days with placebo or 1.0, 10.0 or 20.0 international units (IU) natural human interferon alpha (nHuIFNα). Piglets that were 1–12 days of age and given 1.0, 10.0 or 20.0 IU nHuIFNα had significantly (P < 0.01) greater survival rates than placebo-treated piglets; survival rates were the greater for the highest level of nHuIFNα treatment. In contrast, beneficial effects of nHuIFNα were not observed in piglets farrowed during the disease outbreak and given nHuIFNα within hours of birth. Oral nHuIFNα therapy modulates the natural course of high morbidity and mortality commonly seen with TGE.
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spelling pubmed-71195742020-04-08 Oral treatment of transmissible gastroenteritis with natural human interferon alpha: A field study Cummins, Joseph M. Mock, Richard E. Shive, Bradford W. Krakowka, Steven Richards, Alan B. Hutcheson, David P. Vet Immunol Immunopathol Article During a natural outbreak of transmissible gastroenteritis (TGE), groups of piglets were treated orally for 4 consecutive days with placebo or 1.0, 10.0 or 20.0 international units (IU) natural human interferon alpha (nHuIFNα). Piglets that were 1–12 days of age and given 1.0, 10.0 or 20.0 IU nHuIFNα had significantly (P < 0.01) greater survival rates than placebo-treated piglets; survival rates were the greater for the highest level of nHuIFNα treatment. In contrast, beneficial effects of nHuIFNα were not observed in piglets farrowed during the disease outbreak and given nHuIFNα within hours of birth. Oral nHuIFNα therapy modulates the natural course of high morbidity and mortality commonly seen with TGE. Published by Elsevier B.V. 1995-04 2000-03-10 /pmc/articles/PMC7119574/ /pubmed/7676616 http://dx.doi.org/10.1016/0165-2427(94)05351-R Text en Copyright © 1995 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Cummins, Joseph M.
Mock, Richard E.
Shive, Bradford W.
Krakowka, Steven
Richards, Alan B.
Hutcheson, David P.
Oral treatment of transmissible gastroenteritis with natural human interferon alpha: A field study
title Oral treatment of transmissible gastroenteritis with natural human interferon alpha: A field study
title_full Oral treatment of transmissible gastroenteritis with natural human interferon alpha: A field study
title_fullStr Oral treatment of transmissible gastroenteritis with natural human interferon alpha: A field study
title_full_unstemmed Oral treatment of transmissible gastroenteritis with natural human interferon alpha: A field study
title_short Oral treatment of transmissible gastroenteritis with natural human interferon alpha: A field study
title_sort oral treatment of transmissible gastroenteritis with natural human interferon alpha: a field study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119574/
https://www.ncbi.nlm.nih.gov/pubmed/7676616
http://dx.doi.org/10.1016/0165-2427(94)05351-R
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