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A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination

Although the major isoform of myelin basic protein (MBP) in the healthy adult CNS is the 18.5-kDa protein, other isoforms containing exon 2 encoded protein (21.5 kDa and 20.2 kDa) exist and are expressed primarily during myelin formation. Since remyelination is a prominent feature in MS lesions, we...

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Autores principales: Voskuhl, Rhonda R., McFarlin, Dale E., Tranquill, Laura R., Deibler, Gladys, Stone, Roger, Maloni, Heidi, McFarland, Henry F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119790/
https://www.ncbi.nlm.nih.gov/pubmed/7689584
http://dx.doi.org/10.1016/0165-5728(93)90243-R
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author Voskuhl, Rhonda R.
McFarlin, Dale E.
Tranquill, Laura R.
Deibler, Gladys
Stone, Roger
Maloni, Heidi
McFarland, Henry F.
author_facet Voskuhl, Rhonda R.
McFarlin, Dale E.
Tranquill, Laura R.
Deibler, Gladys
Stone, Roger
Maloni, Heidi
McFarland, Henry F.
author_sort Voskuhl, Rhonda R.
collection PubMed
description Although the major isoform of myelin basic protein (MBP) in the healthy adult CNS is the 18.5-kDa protein, other isoforms containing exon 2 encoded protein (21.5 kDa and 20.2 kDa) exist and are expressed primarily during myelin formation. Since remyelination is a prominent feature in MS lesions, we examined the frequencies of T cell lines (TCLs) specific for epitopes within exon 2 encoded MBP (X2MBP), and also within 18.5-kDa MBP, in members of a multiplex family with MS. TCLs specific for X2MBP were as prevalent as TCLs specific for immunodominant epitopes within 18.5-kDa MBP. In addition, while frequencies of TCLs specific for 18.5-kDa MBP were no different between the affected and unaffected, the frequency of X2MBP-specific TCLs correlated with disease.
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spelling pubmed-71197902020-04-08 A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination Voskuhl, Rhonda R. McFarlin, Dale E. Tranquill, Laura R. Deibler, Gladys Stone, Roger Maloni, Heidi McFarland, Henry F. J Neuroimmunol Article Although the major isoform of myelin basic protein (MBP) in the healthy adult CNS is the 18.5-kDa protein, other isoforms containing exon 2 encoded protein (21.5 kDa and 20.2 kDa) exist and are expressed primarily during myelin formation. Since remyelination is a prominent feature in MS lesions, we examined the frequencies of T cell lines (TCLs) specific for epitopes within exon 2 encoded MBP (X2MBP), and also within 18.5-kDa MBP, in members of a multiplex family with MS. TCLs specific for X2MBP were as prevalent as TCLs specific for immunodominant epitopes within 18.5-kDa MBP. In addition, while frequencies of TCLs specific for 18.5-kDa MBP were no different between the affected and unaffected, the frequency of X2MBP-specific TCLs correlated with disease. Published by Elsevier B.V. 1993-07 2002-12-10 /pmc/articles/PMC7119790/ /pubmed/7689584 http://dx.doi.org/10.1016/0165-5728(93)90243-R Text en Copyright © 1993 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Voskuhl, Rhonda R.
McFarlin, Dale E.
Tranquill, Laura R.
Deibler, Gladys
Stone, Roger
Maloni, Heidi
McFarland, Henry F.
A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination
title A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination
title_full A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination
title_fullStr A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination
title_full_unstemmed A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination
title_short A novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of T-lymphocytes specific for an MBP epitope unique to myelination
title_sort novel candidate autoantigen in a multiplex family with multiple sclerosis: prevalence of t-lymphocytes specific for an mbp epitope unique to myelination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119790/
https://www.ncbi.nlm.nih.gov/pubmed/7689584
http://dx.doi.org/10.1016/0165-5728(93)90243-R
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