Differential modulation of MHC class I antigen expression on mouse brain endothelial cells by MHV-4 infection

Virus-induced modulation of mouse cerebral endothelial cell class I and class II antigens by the neurotropic coronavirus, MHV-4 (JHM), was examined by flow cytometry. In susceptible BALB/c, H-2K(d) was downregulated, while H-2D(d) was upregulated following infection by MHV-4. In contrast, H-2K and H...

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Detalles Bibliográficos
Autores principales: Joseph, J., Knobler, R.L., Lubli, F.D., Hart, M.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1989
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119886/
https://www.ncbi.nlm.nih.gov/pubmed/2539387
http://dx.doi.org/10.1016/0165-5728(89)90022-2
Descripción
Sumario:Virus-induced modulation of mouse cerebral endothelial cell class I and class II antigens by the neurotropic coronavirus, MHV-4 (JHM), was examined by flow cytometry. In susceptible BALB/c, H-2K(d) was downregulated, while H-2D(d) was upregulated following infection by MHV-4. In contrast, H-2K and H-2D antigens were both upregulated in either MHV-4-susceptible B10.S and (BALB/c × SJL) F1, or MHV-4-resistant SJL-derived cerebral endothelial cells following infection with this virus. Class II antigen expression was unchanged following MHV-4 infection. Virus-induced MHC class I modulation is genetically regulated, and may influence virus clearance by class I-dependent CTL.

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