Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes

The effect of tumor necrosis factor (TNF) on expression of major histocompatibility complex (MHC) antigens was examined in mouse glial cells in vitro. TNF induced MHC class I, but not class II, antigen expression on the surface of astrocytes but not on oligodendrocytes. Glial cells do not normally e...

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Detalles Bibliográficos
Autores principales: Lavi, E., Suzumura, A., Murasko, D.M., Murray, E.M., Silberger, D.H., Weiss, S.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1988
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120086/
https://www.ncbi.nlm.nih.gov/pubmed/2452831
http://dx.doi.org/10.1016/0165-5728(88)90102-6
Descripción
Sumario:The effect of tumor necrosis factor (TNF) on expression of major histocompatibility complex (MHC) antigens was examined in mouse glial cells in vitro. TNF induced MHC class I, but not class II, antigen expression on the surface of astrocytes but not on oligodendrocytes. Glial cells do not normally express detectable amounts of MHC antigens. Thus TNF may play a role in the immunopathogenesis of neurologic diseases that involve MHC class I-restricted reactions.

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