Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes

The effect of tumor necrosis factor (TNF) on expression of major histocompatibility complex (MHC) antigens was examined in mouse glial cells in vitro. TNF induced MHC class I, but not class II, antigen expression on the surface of astrocytes but not on oligodendrocytes. Glial cells do not normally e...

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Detalles Bibliográficos
Autores principales: Lavi, E., Suzumura, A., Murasko, D.M., Murray, E.M., Silberger, D.H., Weiss, S.R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 1988
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120086/
https://www.ncbi.nlm.nih.gov/pubmed/2452831
http://dx.doi.org/10.1016/0165-5728(88)90102-6
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author Lavi, E.
Suzumura, A.
Murasko, D.M.
Murray, E.M.
Silberger, D.H.
Weiss, S.R.
author_facet Lavi, E.
Suzumura, A.
Murasko, D.M.
Murray, E.M.
Silberger, D.H.
Weiss, S.R.
author_sort Lavi, E.
collection PubMed
description The effect of tumor necrosis factor (TNF) on expression of major histocompatibility complex (MHC) antigens was examined in mouse glial cells in vitro. TNF induced MHC class I, but not class II, antigen expression on the surface of astrocytes but not on oligodendrocytes. Glial cells do not normally express detectable amounts of MHC antigens. Thus TNF may play a role in the immunopathogenesis of neurologic diseases that involve MHC class I-restricted reactions.
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spelling pubmed-71200862020-04-08 Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes Lavi, E. Suzumura, A. Murasko, D.M. Murray, E.M. Silberger, D.H. Weiss, S.R. J Neuroimmunol Article The effect of tumor necrosis factor (TNF) on expression of major histocompatibility complex (MHC) antigens was examined in mouse glial cells in vitro. TNF induced MHC class I, but not class II, antigen expression on the surface of astrocytes but not on oligodendrocytes. Glial cells do not normally express detectable amounts of MHC antigens. Thus TNF may play a role in the immunopathogenesis of neurologic diseases that involve MHC class I-restricted reactions. Published by Elsevier B.V. 1988-06 2002-11-13 /pmc/articles/PMC7120086/ /pubmed/2452831 http://dx.doi.org/10.1016/0165-5728(88)90102-6 Text en Copyright © 1988 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Lavi, E.
Suzumura, A.
Murasko, D.M.
Murray, E.M.
Silberger, D.H.
Weiss, S.R.
Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes
title Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes
title_full Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes
title_fullStr Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes
title_full_unstemmed Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes
title_short Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes
title_sort tumor necrosis factor induces expression of mhc class i antigens on mouse astrocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120086/
https://www.ncbi.nlm.nih.gov/pubmed/2452831
http://dx.doi.org/10.1016/0165-5728(88)90102-6
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