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The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases

An increasing body of evidence highlights the role of host genetic variation in driving susceptibility to severe disease following pathogen infection. In order to fully appreciate the importance of host genetics on infection susceptibility and resulting disease, genetically variable experimental mod...

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Detalles Bibliográficos
Autores principales: Maurizio, Paul L., Ferris, Martin T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120135/
https://www.ncbi.nlm.nih.gov/pubmed/27933545
http://dx.doi.org/10.1007/978-1-4939-6427-7_28
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author Maurizio, Paul L.
Ferris, Martin T.
author_facet Maurizio, Paul L.
Ferris, Martin T.
author_sort Maurizio, Paul L.
collection PubMed
description An increasing body of evidence highlights the role of host genetic variation in driving susceptibility to severe disease following pathogen infection. In order to fully appreciate the importance of host genetics on infection susceptibility and resulting disease, genetically variable experimental model systems should be employed. These systems allow for the identification, characterization, and mechanistic dissection of genetic variants that cause differential disease responses. Herein we discuss application of the Collaborative Cross (CC) panel of recombinant inbred strains to study viral pathogenesis, focusing on practical considerations for experimental design, assessment and analysis of disease responses within the CC, as well as some of the resources developed for the CC. Although the focus of this chapter is on viral pathogenesis, many of the methods presented within are applicable to studies of other pathogens, as well as to case–control designs in genetically diverse populations.
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spelling pubmed-71201352020-04-06 The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases Maurizio, Paul L. Ferris, Martin T. Systems Genetics Article An increasing body of evidence highlights the role of host genetic variation in driving susceptibility to severe disease following pathogen infection. In order to fully appreciate the importance of host genetics on infection susceptibility and resulting disease, genetically variable experimental model systems should be employed. These systems allow for the identification, characterization, and mechanistic dissection of genetic variants that cause differential disease responses. Herein we discuss application of the Collaborative Cross (CC) panel of recombinant inbred strains to study viral pathogenesis, focusing on practical considerations for experimental design, assessment and analysis of disease responses within the CC, as well as some of the resources developed for the CC. Although the focus of this chapter is on viral pathogenesis, many of the methods presented within are applicable to studies of other pathogens, as well as to case–control designs in genetically diverse populations. 2016-10-17 /pmc/articles/PMC7120135/ /pubmed/27933545 http://dx.doi.org/10.1007/978-1-4939-6427-7_28 Text en © Springer Science+Business Media New York 2017 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Maurizio, Paul L.
Ferris, Martin T.
The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases
title The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases
title_full The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases
title_fullStr The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases
title_full_unstemmed The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases
title_short The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases
title_sort collaborative cross resource for systems genetics research of infectious diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120135/
https://www.ncbi.nlm.nih.gov/pubmed/27933545
http://dx.doi.org/10.1007/978-1-4939-6427-7_28
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