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The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases
An increasing body of evidence highlights the role of host genetic variation in driving susceptibility to severe disease following pathogen infection. In order to fully appreciate the importance of host genetics on infection susceptibility and resulting disease, genetically variable experimental mod...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120135/ https://www.ncbi.nlm.nih.gov/pubmed/27933545 http://dx.doi.org/10.1007/978-1-4939-6427-7_28 |
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author | Maurizio, Paul L. Ferris, Martin T. |
author_facet | Maurizio, Paul L. Ferris, Martin T. |
author_sort | Maurizio, Paul L. |
collection | PubMed |
description | An increasing body of evidence highlights the role of host genetic variation in driving susceptibility to severe disease following pathogen infection. In order to fully appreciate the importance of host genetics on infection susceptibility and resulting disease, genetically variable experimental model systems should be employed. These systems allow for the identification, characterization, and mechanistic dissection of genetic variants that cause differential disease responses. Herein we discuss application of the Collaborative Cross (CC) panel of recombinant inbred strains to study viral pathogenesis, focusing on practical considerations for experimental design, assessment and analysis of disease responses within the CC, as well as some of the resources developed for the CC. Although the focus of this chapter is on viral pathogenesis, many of the methods presented within are applicable to studies of other pathogens, as well as to case–control designs in genetically diverse populations. |
format | Online Article Text |
id | pubmed-7120135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71201352020-04-06 The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases Maurizio, Paul L. Ferris, Martin T. Systems Genetics Article An increasing body of evidence highlights the role of host genetic variation in driving susceptibility to severe disease following pathogen infection. In order to fully appreciate the importance of host genetics on infection susceptibility and resulting disease, genetically variable experimental model systems should be employed. These systems allow for the identification, characterization, and mechanistic dissection of genetic variants that cause differential disease responses. Herein we discuss application of the Collaborative Cross (CC) panel of recombinant inbred strains to study viral pathogenesis, focusing on practical considerations for experimental design, assessment and analysis of disease responses within the CC, as well as some of the resources developed for the CC. Although the focus of this chapter is on viral pathogenesis, many of the methods presented within are applicable to studies of other pathogens, as well as to case–control designs in genetically diverse populations. 2016-10-17 /pmc/articles/PMC7120135/ /pubmed/27933545 http://dx.doi.org/10.1007/978-1-4939-6427-7_28 Text en © Springer Science+Business Media New York 2017 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Maurizio, Paul L. Ferris, Martin T. The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases |
title | The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases |
title_full | The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases |
title_fullStr | The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases |
title_full_unstemmed | The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases |
title_short | The Collaborative Cross Resource for Systems Genetics Research of Infectious Diseases |
title_sort | collaborative cross resource for systems genetics research of infectious diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120135/ https://www.ncbi.nlm.nih.gov/pubmed/27933545 http://dx.doi.org/10.1007/978-1-4939-6427-7_28 |
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