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Sialic Acid Receptors of Viruses
Sialic acid linked to glycoproteins and gangliosides is used by many viruses as a receptor for cell entry. These viruses include important human and animal pathogens, such as influenza, parainfluenza, mumps, corona, noro, rota, and DNA tumor viruses. Attachment to sialic acid is mediated by receptor...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120183/ https://www.ncbi.nlm.nih.gov/pubmed/23873408 http://dx.doi.org/10.1007/128_2013_466 |
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author | Matrosovich, Mikhail Herrler, Georg Klenk, Hans Dieter |
author_facet | Matrosovich, Mikhail Herrler, Georg Klenk, Hans Dieter |
author_sort | Matrosovich, Mikhail |
collection | PubMed |
description | Sialic acid linked to glycoproteins and gangliosides is used by many viruses as a receptor for cell entry. These viruses include important human and animal pathogens, such as influenza, parainfluenza, mumps, corona, noro, rota, and DNA tumor viruses. Attachment to sialic acid is mediated by receptor binding proteins that are constituents of viral envelopes or exposed at the surface of non-enveloped viruses. Some of these viruses are also equipped with a neuraminidase or a sialyl-O-acetyl-esterase. These receptor-destroying enzymes promote virus release from infected cells and neutralize sialic acid-containing soluble proteins interfering with cell surface binding of the virus. Variations in the receptor specificity are important determinants for host range, tissue tropism, pathogenicity, and transmissibility of these viruses. |
format | Online Article Text |
id | pubmed-7120183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71201832020-04-06 Sialic Acid Receptors of Viruses Matrosovich, Mikhail Herrler, Georg Klenk, Hans Dieter SialoGlyco Chemistry and Biology II Article Sialic acid linked to glycoproteins and gangliosides is used by many viruses as a receptor for cell entry. These viruses include important human and animal pathogens, such as influenza, parainfluenza, mumps, corona, noro, rota, and DNA tumor viruses. Attachment to sialic acid is mediated by receptor binding proteins that are constituents of viral envelopes or exposed at the surface of non-enveloped viruses. Some of these viruses are also equipped with a neuraminidase or a sialyl-O-acetyl-esterase. These receptor-destroying enzymes promote virus release from infected cells and neutralize sialic acid-containing soluble proteins interfering with cell surface binding of the virus. Variations in the receptor specificity are important determinants for host range, tissue tropism, pathogenicity, and transmissibility of these viruses. 2013-07-20 /pmc/articles/PMC7120183/ /pubmed/23873408 http://dx.doi.org/10.1007/128_2013_466 Text en © Springer-Verlag Berlin Heidelberg 2013 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Matrosovich, Mikhail Herrler, Georg Klenk, Hans Dieter Sialic Acid Receptors of Viruses |
title | Sialic Acid Receptors of Viruses |
title_full | Sialic Acid Receptors of Viruses |
title_fullStr | Sialic Acid Receptors of Viruses |
title_full_unstemmed | Sialic Acid Receptors of Viruses |
title_short | Sialic Acid Receptors of Viruses |
title_sort | sialic acid receptors of viruses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120183/ https://www.ncbi.nlm.nih.gov/pubmed/23873408 http://dx.doi.org/10.1007/128_2013_466 |
work_keys_str_mv | AT matrosovichmikhail sialicacidreceptorsofviruses AT herrlergeorg sialicacidreceptorsofviruses AT klenkhansdieter sialicacidreceptorsofviruses |