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Functions and Biosynthesis of O-Acetylated Sialic Acids
Sialic acids have a pivotal functional impact in many biological interactions such as virus attachment, cellular adhesion, regulation of proliferation, and apoptosis. A common modification of sialic acids is O-acetylation. O-Acetylated sialic acids occur in bacteria and parasites and are also recept...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120186/ https://www.ncbi.nlm.nih.gov/pubmed/22371169 http://dx.doi.org/10.1007/128_2011_310 |
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author | Mandal, Chitra Schwartz-Albiez, Reinhard Vlasak, Reinhard |
author_facet | Mandal, Chitra Schwartz-Albiez, Reinhard Vlasak, Reinhard |
author_sort | Mandal, Chitra |
collection | PubMed |
description | Sialic acids have a pivotal functional impact in many biological interactions such as virus attachment, cellular adhesion, regulation of proliferation, and apoptosis. A common modification of sialic acids is O-acetylation. O-Acetylated sialic acids occur in bacteria and parasites and are also receptor determinants for a number of viruses. Moreover, they have important functions in embryogenesis, development, and immunological processes. O-Acetylated sialic acids represent cancer markers, as shown for acute lymphoblastic leukemia, and they are known to play significant roles in the regulation of ganglioside-mediated apoptosis. Expression of O-acetylated sialoglycans is regulated by sialic acid-specific O-acetyltransferases and O-acetylesterases. Recent developments in the identification of the enigmatic sialic acid-specific O-acetyltransferase are discussed. |
format | Online Article Text |
id | pubmed-7120186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71201862020-04-06 Functions and Biosynthesis of O-Acetylated Sialic Acids Mandal, Chitra Schwartz-Albiez, Reinhard Vlasak, Reinhard SialoGlyco Chemistry and Biology I Article Sialic acids have a pivotal functional impact in many biological interactions such as virus attachment, cellular adhesion, regulation of proliferation, and apoptosis. A common modification of sialic acids is O-acetylation. O-Acetylated sialic acids occur in bacteria and parasites and are also receptor determinants for a number of viruses. Moreover, they have important functions in embryogenesis, development, and immunological processes. O-Acetylated sialic acids represent cancer markers, as shown for acute lymphoblastic leukemia, and they are known to play significant roles in the regulation of ganglioside-mediated apoptosis. Expression of O-acetylated sialoglycans is regulated by sialic acid-specific O-acetyltransferases and O-acetylesterases. Recent developments in the identification of the enigmatic sialic acid-specific O-acetyltransferase are discussed. 2012-02-28 /pmc/articles/PMC7120186/ /pubmed/22371169 http://dx.doi.org/10.1007/128_2011_310 Text en © Springer-Verlag Berlin Heidelberg 2012 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Mandal, Chitra Schwartz-Albiez, Reinhard Vlasak, Reinhard Functions and Biosynthesis of O-Acetylated Sialic Acids |
title | Functions and Biosynthesis of O-Acetylated Sialic Acids |
title_full | Functions and Biosynthesis of O-Acetylated Sialic Acids |
title_fullStr | Functions and Biosynthesis of O-Acetylated Sialic Acids |
title_full_unstemmed | Functions and Biosynthesis of O-Acetylated Sialic Acids |
title_short | Functions and Biosynthesis of O-Acetylated Sialic Acids |
title_sort | functions and biosynthesis of o-acetylated sialic acids |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120186/ https://www.ncbi.nlm.nih.gov/pubmed/22371169 http://dx.doi.org/10.1007/128_2011_310 |
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