Pleiomorphic viruses revealed by cryo tomography: the structure of coronaviruses

Cryo-electron microscopy has provided in the last decades a wealth of three-dimensional information on viral structures. However, most of this knowledge stems from single particle methods, which rely on averaging and are therefore restricted to viral homogenous structures such as icosahedral capsids...

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Autores principales: Bárcena, M., Baterlink, W., Oostergetel, G. T., Verklijk, A., Rottier, P. J. M., Koster, A. J., Bosch, B. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120210/
http://dx.doi.org/10.1007/978-3-540-85228-5_32
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author Bárcena, M.
Baterlink, W.
Oostergetel, G. T.
Verklijk, A.
Rottier, P. J. M.
Koster, A. J.
Bosch, B. J.
author_facet Bárcena, M.
Baterlink, W.
Oostergetel, G. T.
Verklijk, A.
Rottier, P. J. M.
Koster, A. J.
Bosch, B. J.
author_sort Bárcena, M.
collection PubMed
description Cryo-electron microscopy has provided in the last decades a wealth of three-dimensional information on viral structures. However, most of this knowledge stems from single particle methods, which rely on averaging and are therefore restricted to viral homogenous structures such as icosahedral capsids [1]. This type of analysis excludes pleiomorphic viruses, that is, viruses that, having defined general architectures, arrange their components into different shapes or sizes. Cryo-electron tomography, which provides three-dimensional reconstructions of unique specimens, is now starting to shed light into the structure of this type of viruses [2].
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spelling pubmed-71202102020-04-06 Pleiomorphic viruses revealed by cryo tomography: the structure of coronaviruses Bárcena, M. Baterlink, W. Oostergetel, G. T. Verklijk, A. Rottier, P. J. M. Koster, A. J. Bosch, B. J. EMC 2008 14th European Microscopy Congress 1–5 September 2008, Aachen, Germany Article Cryo-electron microscopy has provided in the last decades a wealth of three-dimensional information on viral structures. However, most of this knowledge stems from single particle methods, which rely on averaging and are therefore restricted to viral homogenous structures such as icosahedral capsids [1]. This type of analysis excludes pleiomorphic viruses, that is, viruses that, having defined general architectures, arrange their components into different shapes or sizes. Cryo-electron tomography, which provides three-dimensional reconstructions of unique specimens, is now starting to shed light into the structure of this type of viruses [2]. 2008 /pmc/articles/PMC7120210/ http://dx.doi.org/10.1007/978-3-540-85228-5_32 Text en © Springer-Verlag Berlin Heidelberg 2008 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Bárcena, M.
Baterlink, W.
Oostergetel, G. T.
Verklijk, A.
Rottier, P. J. M.
Koster, A. J.
Bosch, B. J.
Pleiomorphic viruses revealed by cryo tomography: the structure of coronaviruses
title Pleiomorphic viruses revealed by cryo tomography: the structure of coronaviruses
title_full Pleiomorphic viruses revealed by cryo tomography: the structure of coronaviruses
title_fullStr Pleiomorphic viruses revealed by cryo tomography: the structure of coronaviruses
title_full_unstemmed Pleiomorphic viruses revealed by cryo tomography: the structure of coronaviruses
title_short Pleiomorphic viruses revealed by cryo tomography: the structure of coronaviruses
title_sort pleiomorphic viruses revealed by cryo tomography: the structure of coronaviruses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120210/
http://dx.doi.org/10.1007/978-3-540-85228-5_32
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