Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1

The replication of HIV-1 is strongly enhanced by a small membrane protein called virus protein U (Vpu). Vpu achieves its task by (a) interacting with CD4, the HIV-1 receptor, and (b) by amplifying particle release at the site of the plasma membrane. While the first role is due to interactions of the...

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Detalles Bibliográficos
Autores principales: Lemaitre, V., Kim, C. G., Fischer, D., Lam, Y. H., Watts, A., Fischer, W. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120575/
http://dx.doi.org/10.1007/0-387-28146-0_14
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author Lemaitre, V.
Kim, C. G.
Fischer, D.
Lam, Y. H.
Watts, A.
Fischer, W. B.
author_facet Lemaitre, V.
Kim, C. G.
Fischer, D.
Lam, Y. H.
Watts, A.
Fischer, W. B.
author_sort Lemaitre, V.
collection PubMed
description The replication of HIV-1 is strongly enhanced by a small membrane protein called virus protein U (Vpu). Vpu achieves its task by (a) interacting with CD4, the HIV-1 receptor, and (b) by amplifying particle release at the site of the plasma membrane. While the first role is due to interactions of the cytoplasmic site of Vpu with CD4, the second role may be due to ion channel activity caused by the self-assembly of the protein. Recently, a blocker has been proposed which abolishes channel activity. In this chapter, the mechanism of blocking is described using computational methods, including a brief overview of other viral ion channel blockers.
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spelling pubmed-71205752020-04-06 Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1 Lemaitre, V. Kim, C. G. Fischer, D. Lam, Y. H. Watts, A. Fischer, W. B. Viral Membrane Proteins: Structure, Function, and Drug Design Article The replication of HIV-1 is strongly enhanced by a small membrane protein called virus protein U (Vpu). Vpu achieves its task by (a) interacting with CD4, the HIV-1 receptor, and (b) by amplifying particle release at the site of the plasma membrane. While the first role is due to interactions of the cytoplasmic site of Vpu with CD4, the second role may be due to ion channel activity caused by the self-assembly of the protein. Recently, a blocker has been proposed which abolishes channel activity. In this chapter, the mechanism of blocking is described using computational methods, including a brief overview of other viral ion channel blockers. 2005 /pmc/articles/PMC7120575/ http://dx.doi.org/10.1007/0-387-28146-0_14 Text en © Kluwer Academic/Plenum Publishers, New York 2005 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Lemaitre, V.
Kim, C. G.
Fischer, D.
Lam, Y. H.
Watts, A.
Fischer, W. B.
Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1
title Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1
title_full Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1
title_fullStr Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1
title_full_unstemmed Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1
title_short Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1
title_sort defining drug interactions with the viral membrane protein vpu from hiv-1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120575/
http://dx.doi.org/10.1007/0-387-28146-0_14
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