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Ferrets as a Model for Morbillivirus Pathogenesis, Complications, and Vaccines
The ferret is a standard laboratory animal that can be accommodated in most animal facilities. While not susceptible to measles, ferrets are a natural host of canine distemper virus (CDV), the closely related carnivore morbillivirus. CDV infection in ferrets reproduces all clinical signs associated...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121116/ https://www.ncbi.nlm.nih.gov/pubmed/19203105 http://dx.doi.org/10.1007/978-3-540-70617-5_4 |
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author | Pillet, S. Svitek, N. von Messling, V. |
author_facet | Pillet, S. Svitek, N. von Messling, V. |
author_sort | Pillet, S. |
collection | PubMed |
description | The ferret is a standard laboratory animal that can be accommodated in most animal facilities. While not susceptible to measles, ferrets are a natural host of canine distemper virus (CDV), the closely related carnivore morbillivirus. CDV infection in ferrets reproduces all clinical signs associated with measles in humans, including the typical rash, fever, general immunosuppression, gastrointestinal and respiratory involvement, and neurological complications. Due to this similarity, experimental CDV infection of ferrets is frequently used to assess the efficacy of novel vaccines, and to characterize pathogenesis mechanisms. In addition, direct intracranial inoculation of measles isolates from subacute sclerosing panencephali-tis (SSPE) patients results in an SSPE-like disease in animals that survive the acute phase. Since the advent of reverse genetics systems that allow the targeted manipulation of viral genomes, the model has been used to evaluate the contribution of the accessory proteins C and V, and signalling lymphocyte activation molecule (SLAM)-binding to immunosuppression and overall pathogenesis. Similarly produced green fluorescent protein-expressing derivatives that maintain parental virulence have been instrumental in the direct visualization of systemic dissemination and neuroinvasion. As more immunological tools become available for this model, its contribution to our understanding of morbillivirus—host interactions is expected to increase. |
format | Online Article Text |
id | pubmed-7121116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71211162020-04-06 Ferrets as a Model for Morbillivirus Pathogenesis, Complications, and Vaccines Pillet, S. Svitek, N. von Messling, V. Measles Article The ferret is a standard laboratory animal that can be accommodated in most animal facilities. While not susceptible to measles, ferrets are a natural host of canine distemper virus (CDV), the closely related carnivore morbillivirus. CDV infection in ferrets reproduces all clinical signs associated with measles in humans, including the typical rash, fever, general immunosuppression, gastrointestinal and respiratory involvement, and neurological complications. Due to this similarity, experimental CDV infection of ferrets is frequently used to assess the efficacy of novel vaccines, and to characterize pathogenesis mechanisms. In addition, direct intracranial inoculation of measles isolates from subacute sclerosing panencephali-tis (SSPE) patients results in an SSPE-like disease in animals that survive the acute phase. Since the advent of reverse genetics systems that allow the targeted manipulation of viral genomes, the model has been used to evaluate the contribution of the accessory proteins C and V, and signalling lymphocyte activation molecule (SLAM)-binding to immunosuppression and overall pathogenesis. Similarly produced green fluorescent protein-expressing derivatives that maintain parental virulence have been instrumental in the direct visualization of systemic dissemination and neuroinvasion. As more immunological tools become available for this model, its contribution to our understanding of morbillivirus—host interactions is expected to increase. 2009 /pmc/articles/PMC7121116/ /pubmed/19203105 http://dx.doi.org/10.1007/978-3-540-70617-5_4 Text en © Springer-Verlag Berlin Heidelberg 2009 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Pillet, S. Svitek, N. von Messling, V. Ferrets as a Model for Morbillivirus Pathogenesis, Complications, and Vaccines |
title | Ferrets as a Model for Morbillivirus Pathogenesis, Complications, and Vaccines |
title_full | Ferrets as a Model for Morbillivirus Pathogenesis, Complications, and Vaccines |
title_fullStr | Ferrets as a Model for Morbillivirus Pathogenesis, Complications, and Vaccines |
title_full_unstemmed | Ferrets as a Model for Morbillivirus Pathogenesis, Complications, and Vaccines |
title_short | Ferrets as a Model for Morbillivirus Pathogenesis, Complications, and Vaccines |
title_sort | ferrets as a model for morbillivirus pathogenesis, complications, and vaccines |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121116/ https://www.ncbi.nlm.nih.gov/pubmed/19203105 http://dx.doi.org/10.1007/978-3-540-70617-5_4 |
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