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The Role of Astrocytes, Microglia, and Endothelial Cells in Coronavirus-Induced Demyelination: Induction of cytokines and other signaling mechanisms
Infection of neurotropic strains of coronaviruses in susceptible animals results in acute encephalomyelitis followed by a chronic demyelinating disease, similar to multiple sclerosis (MS). Although the mechanism of chronic coronavirus-induced demyelination is not entirely clear, studies show that it...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2005
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121167/ http://dx.doi.org/10.1007/0-387-25518-4_38 |
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author | Li, Yun Lavi, Ehud |
author_facet | Li, Yun Lavi, Ehud |
author_sort | Li, Yun |
collection | PubMed |
description | Infection of neurotropic strains of coronaviruses in susceptible animals results in acute encephalomyelitis followed by a chronic demyelinating disease, similar to multiple sclerosis (MS). Although the mechanism of chronic coronavirus-induced demyelination is not entirely clear, studies show that it is mostly immune-mediated. Astrocytes, microglia and endothelial cells play an important role in normal functions as well as in immunologic and pathologic processes in the central nervous system (CNS). The interaction between coronaviruses and these cells induces various inflammatory mediators including cytokines, chemokines, MHC and NO, which acting in concert are involved in the pathogenesis of demyelination. |
format | Online Article Text |
id | pubmed-7121167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71211672020-04-06 The Role of Astrocytes, Microglia, and Endothelial Cells in Coronavirus-Induced Demyelination: Induction of cytokines and other signaling mechanisms Li, Yun Lavi, Ehud Experimental Models of Multiple Sclerosis Article Infection of neurotropic strains of coronaviruses in susceptible animals results in acute encephalomyelitis followed by a chronic demyelinating disease, similar to multiple sclerosis (MS). Although the mechanism of chronic coronavirus-induced demyelination is not entirely clear, studies show that it is mostly immune-mediated. Astrocytes, microglia and endothelial cells play an important role in normal functions as well as in immunologic and pathologic processes in the central nervous system (CNS). The interaction between coronaviruses and these cells induces various inflammatory mediators including cytokines, chemokines, MHC and NO, which acting in concert are involved in the pathogenesis of demyelination. 2005 /pmc/articles/PMC7121167/ http://dx.doi.org/10.1007/0-387-25518-4_38 Text en © Springer Science+Business Media, Inc. 2005 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Li, Yun Lavi, Ehud The Role of Astrocytes, Microglia, and Endothelial Cells in Coronavirus-Induced Demyelination: Induction of cytokines and other signaling mechanisms |
title | The Role of Astrocytes, Microglia, and Endothelial Cells in Coronavirus-Induced Demyelination: Induction of cytokines and other signaling mechanisms |
title_full | The Role of Astrocytes, Microglia, and Endothelial Cells in Coronavirus-Induced Demyelination: Induction of cytokines and other signaling mechanisms |
title_fullStr | The Role of Astrocytes, Microglia, and Endothelial Cells in Coronavirus-Induced Demyelination: Induction of cytokines and other signaling mechanisms |
title_full_unstemmed | The Role of Astrocytes, Microglia, and Endothelial Cells in Coronavirus-Induced Demyelination: Induction of cytokines and other signaling mechanisms |
title_short | The Role of Astrocytes, Microglia, and Endothelial Cells in Coronavirus-Induced Demyelination: Induction of cytokines and other signaling mechanisms |
title_sort | role of astrocytes, microglia, and endothelial cells in coronavirus-induced demyelination: induction of cytokines and other signaling mechanisms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121167/ http://dx.doi.org/10.1007/0-387-25518-4_38 |
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