Impact of MicroRNA in Normal and Pathological Respiratory Epithelia

Extensive sequencing efforts, combined with ad hoc bioinformatics developments, have now led to the identification of 1222 distinct miRNAs in human (derived from 1368 distinct genomic loci) and of many miRNAs in other multicellular organisms. The present chapter is aimed at describing a general expe...

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Detalles Bibliográficos
Autores principales: Giovannini-Chami, Lisa, Grandvaux, Nathalie, Zaragosi, Laure-Emmanuelle, Robbe-Sermesant, Karine, Marcet, Brice, Cardinaud, Bruno, Coraux, Christelle, Berthiaume, Yves, Waldmann, Rainer, Mari, Bernard, Barbry, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121186/
https://www.ncbi.nlm.nih.gov/pubmed/21594785
http://dx.doi.org/10.1007/978-1-61779-117-8_12
Descripción
Sumario:Extensive sequencing efforts, combined with ad hoc bioinformatics developments, have now led to the identification of 1222 distinct miRNAs in human (derived from 1368 distinct genomic loci) and of many miRNAs in other multicellular organisms. The present chapter is aimed at describing a general experimental strategy to identify specific miRNA expression profiles and to highlight the functional networks operating between them and their mRNA targets, including several miRNAs deregulated in cystic fibrosis and during differentiation of airway epithelial cells.

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