Impact of MicroRNA in Normal and Pathological Respiratory Epithelia

Extensive sequencing efforts, combined with ad hoc bioinformatics developments, have now led to the identification of 1222 distinct miRNAs in human (derived from 1368 distinct genomic loci) and of many miRNAs in other multicellular organisms. The present chapter is aimed at describing a general expe...

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Autores principales: Giovannini-Chami, Lisa, Grandvaux, Nathalie, Zaragosi, Laure-Emmanuelle, Robbe-Sermesant, Karine, Marcet, Brice, Cardinaud, Bruno, Coraux, Christelle, Berthiaume, Yves, Waldmann, Rainer, Mari, Bernard, Barbry, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121186/
https://www.ncbi.nlm.nih.gov/pubmed/21594785
http://dx.doi.org/10.1007/978-1-61779-117-8_12
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author Giovannini-Chami, Lisa
Grandvaux, Nathalie
Zaragosi, Laure-Emmanuelle
Robbe-Sermesant, Karine
Marcet, Brice
Cardinaud, Bruno
Coraux, Christelle
Berthiaume, Yves
Waldmann, Rainer
Mari, Bernard
Barbry, Pascal
author_facet Giovannini-Chami, Lisa
Grandvaux, Nathalie
Zaragosi, Laure-Emmanuelle
Robbe-Sermesant, Karine
Marcet, Brice
Cardinaud, Bruno
Coraux, Christelle
Berthiaume, Yves
Waldmann, Rainer
Mari, Bernard
Barbry, Pascal
author_sort Giovannini-Chami, Lisa
collection PubMed
description Extensive sequencing efforts, combined with ad hoc bioinformatics developments, have now led to the identification of 1222 distinct miRNAs in human (derived from 1368 distinct genomic loci) and of many miRNAs in other multicellular organisms. The present chapter is aimed at describing a general experimental strategy to identify specific miRNA expression profiles and to highlight the functional networks operating between them and their mRNA targets, including several miRNAs deregulated in cystic fibrosis and during differentiation of airway epithelial cells.
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spelling pubmed-71211862020-04-06 Impact of MicroRNA in Normal and Pathological Respiratory Epithelia Giovannini-Chami, Lisa Grandvaux, Nathalie Zaragosi, Laure-Emmanuelle Robbe-Sermesant, Karine Marcet, Brice Cardinaud, Bruno Coraux, Christelle Berthiaume, Yves Waldmann, Rainer Mari, Bernard Barbry, Pascal Cystic Fibrosis Article Extensive sequencing efforts, combined with ad hoc bioinformatics developments, have now led to the identification of 1222 distinct miRNAs in human (derived from 1368 distinct genomic loci) and of many miRNAs in other multicellular organisms. The present chapter is aimed at describing a general experimental strategy to identify specific miRNA expression profiles and to highlight the functional networks operating between them and their mRNA targets, including several miRNAs deregulated in cystic fibrosis and during differentiation of airway epithelial cells. 2011-01-19 /pmc/articles/PMC7121186/ /pubmed/21594785 http://dx.doi.org/10.1007/978-1-61779-117-8_12 Text en © Springer Science+Business Media, LLC 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Giovannini-Chami, Lisa
Grandvaux, Nathalie
Zaragosi, Laure-Emmanuelle
Robbe-Sermesant, Karine
Marcet, Brice
Cardinaud, Bruno
Coraux, Christelle
Berthiaume, Yves
Waldmann, Rainer
Mari, Bernard
Barbry, Pascal
Impact of MicroRNA in Normal and Pathological Respiratory Epithelia
title Impact of MicroRNA in Normal and Pathological Respiratory Epithelia
title_full Impact of MicroRNA in Normal and Pathological Respiratory Epithelia
title_fullStr Impact of MicroRNA in Normal and Pathological Respiratory Epithelia
title_full_unstemmed Impact of MicroRNA in Normal and Pathological Respiratory Epithelia
title_short Impact of MicroRNA in Normal and Pathological Respiratory Epithelia
title_sort impact of microrna in normal and pathological respiratory epithelia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121186/
https://www.ncbi.nlm.nih.gov/pubmed/21594785
http://dx.doi.org/10.1007/978-1-61779-117-8_12
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