The RPE Cell and the Immune System

The RPE cell plays a pivotal role in retinal immunity. In fact, the RPE cell orchestrates both innate and adaptive immunity and contains a plethora of factors to regulate the immune response. Many immunoregulatory activities of the RPE cell are accomplished through cytokine production, toll-like rec...

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Detalles Bibliográficos
Autores principales: Detrick, Barbara, Hooks, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121222/
http://dx.doi.org/10.1007/978-3-030-28384-1_6
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author Detrick, Barbara
Hooks, John J.
author_facet Detrick, Barbara
Hooks, John J.
author_sort Detrick, Barbara
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description The RPE cell plays a pivotal role in retinal immunity. In fact, the RPE cell orchestrates both innate and adaptive immunity and contains a plethora of factors to regulate the immune response. Many immunoregulatory activities of the RPE cell are accomplished through cytokine production, toll-like receptor (TLR) activation, complement regulation and antigen presentation. The RPE cells immune regulatory network plays an essential role in retinal immunity and autoimmunity, retinal infections and in a variety of retinal degenerative disorders. Understanding the immune regulatory properties of this cell may provide additional clues to disease mechanisms that may lead to future treatments for many human retinal diseases.
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spelling pubmed-71212222020-04-06 The RPE Cell and the Immune System Detrick, Barbara Hooks, John J. Retinal Pigment Epithelium in Health and Disease Article The RPE cell plays a pivotal role in retinal immunity. In fact, the RPE cell orchestrates both innate and adaptive immunity and contains a plethora of factors to regulate the immune response. Many immunoregulatory activities of the RPE cell are accomplished through cytokine production, toll-like receptor (TLR) activation, complement regulation and antigen presentation. The RPE cells immune regulatory network plays an essential role in retinal immunity and autoimmunity, retinal infections and in a variety of retinal degenerative disorders. Understanding the immune regulatory properties of this cell may provide additional clues to disease mechanisms that may lead to future treatments for many human retinal diseases. 2019-07-31 /pmc/articles/PMC7121222/ http://dx.doi.org/10.1007/978-3-030-28384-1_6 Text en © Springer Nature Switzerland AG 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Detrick, Barbara
Hooks, John J.
The RPE Cell and the Immune System
title The RPE Cell and the Immune System
title_full The RPE Cell and the Immune System
title_fullStr The RPE Cell and the Immune System
title_full_unstemmed The RPE Cell and the Immune System
title_short The RPE Cell and the Immune System
title_sort rpe cell and the immune system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121222/
http://dx.doi.org/10.1007/978-3-030-28384-1_6
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