Industrial Production of Therapeutic Proteins: Cell Lines, Cell Culture, and Purification

A central pillar of the biotechnology and pharmaceutical industries continues to be the development of biological drug products manufactured from engineered mammalian cell lines. Since the hugely successful launch of human tissue plasminogen activator in 1987 and erythropoietin in 1988, the biopharm...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Marie M., Mollet, Michael, Hubert, Rene S., Kyung, Yun Seung, Zhang, Green G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121293/
http://dx.doi.org/10.1007/978-3-319-52287-6_29
_version_ 1783515169067892736
author Zhu, Marie M.
Mollet, Michael
Hubert, Rene S.
Kyung, Yun Seung
Zhang, Green G.
author_facet Zhu, Marie M.
Mollet, Michael
Hubert, Rene S.
Kyung, Yun Seung
Zhang, Green G.
author_sort Zhu, Marie M.
collection PubMed
description A central pillar of the biotechnology and pharmaceutical industries continues to be the development of biological drug products manufactured from engineered mammalian cell lines. Since the hugely successful launch of human tissue plasminogen activator in 1987 and erythropoietin in 1988, the biopharmaceutical market has grown immensely. In 2014, biotherapeutics made up a significant portion of global drug sales as 7 of the top 10 and 21 of top 50 selling pharmaceuticals in the world were biologics with over US$100 billion in global sales (Table 1, [1]).
format Online
Article
Text
id pubmed-7121293
institution National Center for Biotechnology Information
language English
publishDate 2017
record_format MEDLINE/PubMed
spelling pubmed-71212932020-04-06 Industrial Production of Therapeutic Proteins: Cell Lines, Cell Culture, and Purification Zhu, Marie M. Mollet, Michael Hubert, Rene S. Kyung, Yun Seung Zhang, Green G. Handbook of Industrial Chemistry and Biotechnology Article A central pillar of the biotechnology and pharmaceutical industries continues to be the development of biological drug products manufactured from engineered mammalian cell lines. Since the hugely successful launch of human tissue plasminogen activator in 1987 and erythropoietin in 1988, the biopharmaceutical market has grown immensely. In 2014, biotherapeutics made up a significant portion of global drug sales as 7 of the top 10 and 21 of top 50 selling pharmaceuticals in the world were biologics with over US$100 billion in global sales (Table 1, [1]). 2017-05-03 /pmc/articles/PMC7121293/ http://dx.doi.org/10.1007/978-3-319-52287-6_29 Text en © Springer International Publishing AG 2017 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Zhu, Marie M.
Mollet, Michael
Hubert, Rene S.
Kyung, Yun Seung
Zhang, Green G.
Industrial Production of Therapeutic Proteins: Cell Lines, Cell Culture, and Purification
title Industrial Production of Therapeutic Proteins: Cell Lines, Cell Culture, and Purification
title_full Industrial Production of Therapeutic Proteins: Cell Lines, Cell Culture, and Purification
title_fullStr Industrial Production of Therapeutic Proteins: Cell Lines, Cell Culture, and Purification
title_full_unstemmed Industrial Production of Therapeutic Proteins: Cell Lines, Cell Culture, and Purification
title_short Industrial Production of Therapeutic Proteins: Cell Lines, Cell Culture, and Purification
title_sort industrial production of therapeutic proteins: cell lines, cell culture, and purification
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121293/
http://dx.doi.org/10.1007/978-3-319-52287-6_29
work_keys_str_mv AT zhumariem industrialproductionoftherapeuticproteinscelllinescellcultureandpurification
AT molletmichael industrialproductionoftherapeuticproteinscelllinescellcultureandpurification
AT hubertrenes industrialproductionoftherapeuticproteinscelllinescellcultureandpurification
AT kyungyunseung industrialproductionoftherapeuticproteinscelllinescellcultureandpurification
AT zhanggreeng industrialproductionoftherapeuticproteinscelllinescellcultureandpurification

Ejemplares similares