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The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly
Infectious diseases still represent a major challenge to human progress and survival. Especially elderly persons are more frequently and severely affected by infectious diseases and they display distinct features with respect to clinical presentation and treatment. Although vaccinations are consider...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121339/ http://dx.doi.org/10.1007/978-0-387-76842-7_10 |
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author | Herndler-Brandstetter, Dietmar Grubeck-Loebenstein, Beatrix |
author_facet | Herndler-Brandstetter, Dietmar Grubeck-Loebenstein, Beatrix |
author_sort | Herndler-Brandstetter, Dietmar |
collection | PubMed |
description | Infectious diseases still represent a major challenge to human progress and survival. Especially elderly persons are more frequently and severely affected by infectious diseases and they display distinct features with respect to clinical presentation and treatment. Although vaccinations are considered a vital medical procedure for preventing morbidity and mortality caused by infectious diseases, the protective effect of vaccinations is abrogated in elderly persons. This is due to a decline in the functions of the immune system referred to as immunosenescence. The first part of this chapter will therefore summarize the status quo of the efficacy of vaccines in preventing morbidity and mortality caused by typical infectious diseases in the elderly, such as influenza, pneumonia and tuberculosis. The second part will then elucidate the underlying age-related mechanisms which may contribute to the decreased efficacy of vaccines. Based on the complex mechanisms involved in immunosenescence, strategies will be outlined which may be succesfful in enhancing protective immune responses following vaccination in elderly persons. |
format | Online Article Text |
id | pubmed-7121339 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71213392020-04-06 The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly Herndler-Brandstetter, Dietmar Grubeck-Loebenstein, Beatrix Immunosenescence Article Infectious diseases still represent a major challenge to human progress and survival. Especially elderly persons are more frequently and severely affected by infectious diseases and they display distinct features with respect to clinical presentation and treatment. Although vaccinations are considered a vital medical procedure for preventing morbidity and mortality caused by infectious diseases, the protective effect of vaccinations is abrogated in elderly persons. This is due to a decline in the functions of the immune system referred to as immunosenescence. The first part of this chapter will therefore summarize the status quo of the efficacy of vaccines in preventing morbidity and mortality caused by typical infectious diseases in the elderly, such as influenza, pneumonia and tuberculosis. The second part will then elucidate the underlying age-related mechanisms which may contribute to the decreased efficacy of vaccines. Based on the complex mechanisms involved in immunosenescence, strategies will be outlined which may be succesfful in enhancing protective immune responses following vaccination in elderly persons. 2007 /pmc/articles/PMC7121339/ http://dx.doi.org/10.1007/978-0-387-76842-7_10 Text en © Landes Bioscience and Springer Science+Business Media 2007 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Herndler-Brandstetter, Dietmar Grubeck-Loebenstein, Beatrix The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly |
title | The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly |
title_full | The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly |
title_fullStr | The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly |
title_full_unstemmed | The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly |
title_short | The Efficacy of Vaccines to Prevent Infectious Diseases in the Elderly |
title_sort | efficacy of vaccines to prevent infectious diseases in the elderly |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121339/ http://dx.doi.org/10.1007/978-0-387-76842-7_10 |
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