The Zincins: Collagen Fiber Processing and Degradation

This chapter discusses the zinc-containing metalloendoproteinases. These enzymes remodel the stroma during development and around tissues that have been injured or stressed. Section 1 describes the three major classes of metalloproteases, their metal ion cofactors, their functions in biology, and th...

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Detalles Bibliográficos
Autor principal: Levine, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121358/
http://dx.doi.org/10.1007/978-3-540-88116-2_8
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author Levine, Martin
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description This chapter discusses the zinc-containing metalloendoproteinases. These enzymes remodel the stroma during development and around tissues that have been injured or stressed. Section 1 describes the three major classes of metalloproteases, their metal ion cofactors, their functions in biology, and the metzincin catalytic mechanism in procollagen and stromal protein processing. Section 2 describes the astacin and adamalysin metzincin subclasses and how they process procollagen to tropocollagen. Section 3 describes the matrilysin metzincin subclass and their roles in collagen and stromal tissue degradation and in enamel synthesis.
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spelling pubmed-71213582020-04-06 The Zincins: Collagen Fiber Processing and Degradation Levine, Martin Topics in Dental Biochemistry Article This chapter discusses the zinc-containing metalloendoproteinases. These enzymes remodel the stroma during development and around tissues that have been injured or stressed. Section 1 describes the three major classes of metalloproteases, their metal ion cofactors, their functions in biology, and the metzincin catalytic mechanism in procollagen and stromal protein processing. Section 2 describes the astacin and adamalysin metzincin subclasses and how they process procollagen to tropocollagen. Section 3 describes the matrilysin metzincin subclass and their roles in collagen and stromal tissue degradation and in enamel synthesis. 2010-10-15 /pmc/articles/PMC7121358/ http://dx.doi.org/10.1007/978-3-540-88116-2_8 Text en © Springer Berlin Heidelberg 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Levine, Martin
The Zincins: Collagen Fiber Processing and Degradation
title The Zincins: Collagen Fiber Processing and Degradation
title_full The Zincins: Collagen Fiber Processing and Degradation
title_fullStr The Zincins: Collagen Fiber Processing and Degradation
title_full_unstemmed The Zincins: Collagen Fiber Processing and Degradation
title_short The Zincins: Collagen Fiber Processing and Degradation
title_sort zincins: collagen fiber processing and degradation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121358/
http://dx.doi.org/10.1007/978-3-540-88116-2_8
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