Animal Models of Multiple Sclerosis

To determine whether an immunological or pharmaceutical product has potential for therapy in treating multiple sclerosis (MS), detailed animal models are required. To date many animal models for human MS have been described in mice, rats, rabbits, guinea pigs, marmosets, and rhesus monkeys. The most...

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Detalles Bibliográficos
Autores principales: Young, Colin R., Welsh, C. Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121393/
http://dx.doi.org/10.1007/978-1-59745-285-4_69
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author Young, Colin R.
Welsh, C. Jane
author_facet Young, Colin R.
Welsh, C. Jane
author_sort Young, Colin R.
collection PubMed
description To determine whether an immunological or pharmaceutical product has potential for therapy in treating multiple sclerosis (MS), detailed animal models are required. To date many animal models for human MS have been described in mice, rats, rabbits, guinea pigs, marmosets, and rhesus monkeys. The most comprehensive studies have involved murine experimental allergic (or autoimmune) encephalomyelitis (EAE), Semliki Forest virus (SFV), mouse hepatitis virus (MHV), and Theiler’s murine encephalomyelitis virus (TMEV). Here, we describe in detail multispecies animal models of human MS, namely EAE, SFV, MHV, and TMEV, in addition to chemically induced demyelination. The validity and applicability of each of these models are critically evaluated.
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spelling pubmed-71213932020-04-06 Animal Models of Multiple Sclerosis Young, Colin R. Welsh, C. Jane Sourcebook of Models for Biomedical Research Article To determine whether an immunological or pharmaceutical product has potential for therapy in treating multiple sclerosis (MS), detailed animal models are required. To date many animal models for human MS have been described in mice, rats, rabbits, guinea pigs, marmosets, and rhesus monkeys. The most comprehensive studies have involved murine experimental allergic (or autoimmune) encephalomyelitis (EAE), Semliki Forest virus (SFV), mouse hepatitis virus (MHV), and Theiler’s murine encephalomyelitis virus (TMEV). Here, we describe in detail multispecies animal models of human MS, namely EAE, SFV, MHV, and TMEV, in addition to chemically induced demyelination. The validity and applicability of each of these models are critically evaluated. 2008 /pmc/articles/PMC7121393/ http://dx.doi.org/10.1007/978-1-59745-285-4_69 Text en © Humana Press Inc., Totowa, NJ 2008 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Young, Colin R.
Welsh, C. Jane
Animal Models of Multiple Sclerosis
title Animal Models of Multiple Sclerosis
title_full Animal Models of Multiple Sclerosis
title_fullStr Animal Models of Multiple Sclerosis
title_full_unstemmed Animal Models of Multiple Sclerosis
title_short Animal Models of Multiple Sclerosis
title_sort animal models of multiple sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121393/
http://dx.doi.org/10.1007/978-1-59745-285-4_69
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