Cargando…
Origins of the regulated secretory pathway
Modes of transport of soluble (or luminal) secretory proteins synthesized in the endoplasmic reticulum (ER) could be divided into two groups. The socalled constitutive secretory pathway (CSP) is common to all eukaryotic cells, constantly delivering constitutive soluble secretory proteins (CSSPs) lin...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121582/ http://dx.doi.org/10.1007/978-3-211-76310-0_30 |
_version_ | 1783515234617524224 |
---|---|
author | Mironov, Alexander A. Arvan, Peter |
author_facet | Mironov, Alexander A. Arvan, Peter |
author_sort | Mironov, Alexander A. |
collection | PubMed |
description | Modes of transport of soluble (or luminal) secretory proteins synthesized in the endoplasmic reticulum (ER) could be divided into two groups. The socalled constitutive secretory pathway (CSP) is common to all eukaryotic cells, constantly delivering constitutive soluble secretory proteins (CSSPs) linked to the rate of protein synthesis but largely independent of external stimuli. In regulated secretion, protein is sorted from the Golgi into storage/secretory granules (SGs) whose contents are released when stimuli trigger their final fusion with the plasma membrane (Hannah et al. 1999). |
format | Online Article Text |
id | pubmed-7121582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71215822020-04-06 Origins of the regulated secretory pathway Mironov, Alexander A. Arvan, Peter The Golgi Apparatus Article Modes of transport of soluble (or luminal) secretory proteins synthesized in the endoplasmic reticulum (ER) could be divided into two groups. The socalled constitutive secretory pathway (CSP) is common to all eukaryotic cells, constantly delivering constitutive soluble secretory proteins (CSSPs) linked to the rate of protein synthesis but largely independent of external stimuli. In regulated secretion, protein is sorted from the Golgi into storage/secretory granules (SGs) whose contents are released when stimuli trigger their final fusion with the plasma membrane (Hannah et al. 1999). 2008 /pmc/articles/PMC7121582/ http://dx.doi.org/10.1007/978-3-211-76310-0_30 Text en © Springer-Verlag/Wien 2008 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Mironov, Alexander A. Arvan, Peter Origins of the regulated secretory pathway |
title | Origins of the regulated secretory pathway |
title_full | Origins of the regulated secretory pathway |
title_fullStr | Origins of the regulated secretory pathway |
title_full_unstemmed | Origins of the regulated secretory pathway |
title_short | Origins of the regulated secretory pathway |
title_sort | origins of the regulated secretory pathway |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121582/ http://dx.doi.org/10.1007/978-3-211-76310-0_30 |
work_keys_str_mv | AT mironovalexandera originsoftheregulatedsecretorypathway AT arvanpeter originsoftheregulatedsecretorypathway |