Autoimmune Processes in the Central Nervous System

In this chapter we discuss the factors that contribute to the unique immunological environment of the central nervous system and the mechanisms that may account for the development of autoimmunity within the CNS, including infectious agents as inducers of autoimmune disease. Consideration is given t...

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Autores principales: Welsh, C. J., Young, C. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121640/
http://dx.doi.org/10.1007/978-0-387-30398-7_15
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author Welsh, C. J.
Young, C. R.
author_facet Welsh, C. J.
Young, C. R.
author_sort Welsh, C. J.
collection PubMed
description In this chapter we discuss the factors that contribute to the unique immunological environment of the central nervous system and the mechanisms that may account for the development of autoimmunity within the CNS, including infectious agents as inducers of autoimmune disease. Consideration is given to a variety of human neurological diseases of autoimmune or presumed autoimmune etiology: autism, neuromyelitis optica, neuromyotonia, schizophrenia, lethargic encephalitis and stiff‐man syndrome. Also, we discuss autoimmunity as a possible mediator of CNS repair and examples of the protective effects of bacterial and helminth infections on CNS disease. Multiple sclerosis and models of multiple sclerosis are discussed with special attention given to the Theiler's virus‐induced demyelination model.
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spelling pubmed-71216402020-04-06 Autoimmune Processes in the Central Nervous System Welsh, C. J. Young, C. R. Handbook of Neurochemistry and Molecular Neurobiology Article In this chapter we discuss the factors that contribute to the unique immunological environment of the central nervous system and the mechanisms that may account for the development of autoimmunity within the CNS, including infectious agents as inducers of autoimmune disease. Consideration is given to a variety of human neurological diseases of autoimmune or presumed autoimmune etiology: autism, neuromyelitis optica, neuromyotonia, schizophrenia, lethargic encephalitis and stiff‐man syndrome. Also, we discuss autoimmunity as a possible mediator of CNS repair and examples of the protective effects of bacterial and helminth infections on CNS disease. Multiple sclerosis and models of multiple sclerosis are discussed with special attention given to the Theiler's virus‐induced demyelination model. 2008 /pmc/articles/PMC7121640/ http://dx.doi.org/10.1007/978-0-387-30398-7_15 Text en © Springer Science+Business Media, LLC 2008 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Welsh, C. J.
Young, C. R.
Autoimmune Processes in the Central Nervous System
title Autoimmune Processes in the Central Nervous System
title_full Autoimmune Processes in the Central Nervous System
title_fullStr Autoimmune Processes in the Central Nervous System
title_full_unstemmed Autoimmune Processes in the Central Nervous System
title_short Autoimmune Processes in the Central Nervous System
title_sort autoimmune processes in the central nervous system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121640/
http://dx.doi.org/10.1007/978-0-387-30398-7_15
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