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Investigation of Parameters that Affect Resin Swelling in Green Solvents

The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger...

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Autores principales: Amadi‐Kamalu, Chidi, Clarke, Holly, McRobie, Matthew, Mortimer, James, North, Michael, Ran, Yanrui, Routledge, Anne, Sibbald, Dani, Tickias, Matthew, Tse, Kai, Willway, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121665/
https://www.ncbi.nlm.nih.gov/pubmed/32257751
http://dx.doi.org/10.1002/open.202000030
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author Amadi‐Kamalu, Chidi
Clarke, Holly
McRobie, Matthew
Mortimer, James
North, Michael
Ran, Yanrui
Routledge, Anne
Sibbald, Dani
Tickias, Matthew
Tse, Kai
Willway, Helen
author_facet Amadi‐Kamalu, Chidi
Clarke, Holly
McRobie, Matthew
Mortimer, James
North, Michael
Ran, Yanrui
Routledge, Anne
Sibbald, Dani
Tickias, Matthew
Tse, Kai
Willway, Helen
author_sort Amadi‐Kamalu, Chidi
collection PubMed
description The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.
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spelling pubmed-71216652020-04-06 Investigation of Parameters that Affect Resin Swelling in Green Solvents Amadi‐Kamalu, Chidi Clarke, Holly McRobie, Matthew Mortimer, James North, Michael Ran, Yanrui Routledge, Anne Sibbald, Dani Tickias, Matthew Tse, Kai Willway, Helen ChemistryOpen Full Papers The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis. John Wiley and Sons Inc. 2020-04-03 /pmc/articles/PMC7121665/ /pubmed/32257751 http://dx.doi.org/10.1002/open.202000030 Text en © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Full Papers
Amadi‐Kamalu, Chidi
Clarke, Holly
McRobie, Matthew
Mortimer, James
North, Michael
Ran, Yanrui
Routledge, Anne
Sibbald, Dani
Tickias, Matthew
Tse, Kai
Willway, Helen
Investigation of Parameters that Affect Resin Swelling in Green Solvents
title Investigation of Parameters that Affect Resin Swelling in Green Solvents
title_full Investigation of Parameters that Affect Resin Swelling in Green Solvents
title_fullStr Investigation of Parameters that Affect Resin Swelling in Green Solvents
title_full_unstemmed Investigation of Parameters that Affect Resin Swelling in Green Solvents
title_short Investigation of Parameters that Affect Resin Swelling in Green Solvents
title_sort investigation of parameters that affect resin swelling in green solvents
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121665/
https://www.ncbi.nlm.nih.gov/pubmed/32257751
http://dx.doi.org/10.1002/open.202000030
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