Coronavirus-Induced Demyelination and Spontaneous Remyelination: Growth factor expression and function

MHV-A59 coronavirus infection produces a transient episode of demyelination that is followed by spontaneous remyelination. This paradigm provides a complex lesion environment to examine cellular and molecular mechanisms involved in successful CNS remyelination. Our work in this model has focused on...

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Detalles Bibliográficos
Autores principales: Armstrong, Regina C., Redwine, Jeffrey M., Messersmith, Donna J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121801/
http://dx.doi.org/10.1007/0-387-25518-4_44
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author Armstrong, Regina C.
Redwine, Jeffrey M.
Messersmith, Donna J.
author_facet Armstrong, Regina C.
Redwine, Jeffrey M.
Messersmith, Donna J.
author_sort Armstrong, Regina C.
collection PubMed
description MHV-A59 coronavirus infection produces a transient episode of demyelination that is followed by spontaneous remyelination. This paradigm provides a complex lesion environment to examine cellular and molecular mechanisms involved in successful CNS remyelination. Our work in this model has focused on the roles of platelet-derived growth factor and fibroblast growth factor 2 in regulating oligodendrocyte progenitor responses required for remyelination.
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spelling pubmed-71218012020-04-06 Coronavirus-Induced Demyelination and Spontaneous Remyelination: Growth factor expression and function Armstrong, Regina C. Redwine, Jeffrey M. Messersmith, Donna J. Experimental Models of Multiple Sclerosis Article MHV-A59 coronavirus infection produces a transient episode of demyelination that is followed by spontaneous remyelination. This paradigm provides a complex lesion environment to examine cellular and molecular mechanisms involved in successful CNS remyelination. Our work in this model has focused on the roles of platelet-derived growth factor and fibroblast growth factor 2 in regulating oligodendrocyte progenitor responses required for remyelination. 2005 /pmc/articles/PMC7121801/ http://dx.doi.org/10.1007/0-387-25518-4_44 Text en © Springer Science+Business Media, Inc. 2005 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Armstrong, Regina C.
Redwine, Jeffrey M.
Messersmith, Donna J.
Coronavirus-Induced Demyelination and Spontaneous Remyelination: Growth factor expression and function
title Coronavirus-Induced Demyelination and Spontaneous Remyelination: Growth factor expression and function
title_full Coronavirus-Induced Demyelination and Spontaneous Remyelination: Growth factor expression and function
title_fullStr Coronavirus-Induced Demyelination and Spontaneous Remyelination: Growth factor expression and function
title_full_unstemmed Coronavirus-Induced Demyelination and Spontaneous Remyelination: Growth factor expression and function
title_short Coronavirus-Induced Demyelination and Spontaneous Remyelination: Growth factor expression and function
title_sort coronavirus-induced demyelination and spontaneous remyelination: growth factor expression and function
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121801/
http://dx.doi.org/10.1007/0-387-25518-4_44
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