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Measles Studies in the Macaque Model

Much of our current understanding of measles has come from experiments in non-human primates. In 1911, Goldberger and Anderson showed that macaques inoculated with filtered secretions from measles patients developed measles, thus demonstrating that the causative agent of this disease was a virus. Si...

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Autor principal: de Swart, R. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122137/
https://www.ncbi.nlm.nih.gov/pubmed/19203104
http://dx.doi.org/10.1007/978-3-540-70617-5_3
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author de Swart, R. L.
author_facet de Swart, R. L.
author_sort de Swart, R. L.
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description Much of our current understanding of measles has come from experiments in non-human primates. In 1911, Goldberger and Anderson showed that macaques inoculated with filtered secretions from measles patients developed measles, thus demonstrating that the causative agent of this disease was a virus. Since then, different monkey species have been used for experimental measles virus infections. Moreover, infection studies in macaques demonstrated that serial passage of the virus in vivo and in vitro resulted in virus attenuation, providing the basis for all current live-attenuated measles vaccines. This chapter will review the macaque model for measles, with a focus on vaccination and immunopathogenesis studies conducted over the last 15 years. In addition, recent data are highlighted demonstrating that the application of a recombinant measles virus strain expressing enhanced green fluorescent protein dramatically increased the sensitivity of virus detection, both in living and sacrificed animals, allowing new approaches to old questions on measles vaccination and pathogenesis.
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spelling pubmed-71221372020-04-06 Measles Studies in the Macaque Model de Swart, R. L. Measles Article Much of our current understanding of measles has come from experiments in non-human primates. In 1911, Goldberger and Anderson showed that macaques inoculated with filtered secretions from measles patients developed measles, thus demonstrating that the causative agent of this disease was a virus. Since then, different monkey species have been used for experimental measles virus infections. Moreover, infection studies in macaques demonstrated that serial passage of the virus in vivo and in vitro resulted in virus attenuation, providing the basis for all current live-attenuated measles vaccines. This chapter will review the macaque model for measles, with a focus on vaccination and immunopathogenesis studies conducted over the last 15 years. In addition, recent data are highlighted demonstrating that the application of a recombinant measles virus strain expressing enhanced green fluorescent protein dramatically increased the sensitivity of virus detection, both in living and sacrificed animals, allowing new approaches to old questions on measles vaccination and pathogenesis. 2009 /pmc/articles/PMC7122137/ /pubmed/19203104 http://dx.doi.org/10.1007/978-3-540-70617-5_3 Text en © Springer-Verlag Berlin Heidelberg 2009 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
de Swart, R. L.
Measles Studies in the Macaque Model
title Measles Studies in the Macaque Model
title_full Measles Studies in the Macaque Model
title_fullStr Measles Studies in the Macaque Model
title_full_unstemmed Measles Studies in the Macaque Model
title_short Measles Studies in the Macaque Model
title_sort measles studies in the macaque model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122137/
https://www.ncbi.nlm.nih.gov/pubmed/19203104
http://dx.doi.org/10.1007/978-3-540-70617-5_3
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