Cargando…

Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1

The currently available anti-HIV-1 therapeutics is highly beneficial to infected patients. However, clinical failures occur as a result of the ability of HIV-1 to rapidly mutate. One approach to overcome drug resistance is to target HIV-1 proteins that are highly conserved among phylogenetically dis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mori, Mattia, Kovalenko, Lesia, Lyonnais, Sébastien, Antaki, Danny, Torbett, Bruce E., Botta, Maurizio, Mirambeau, Gilles, Mély, Yves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122173/ https://www.ncbi.nlm.nih.gov/pubmed/25749978 http://dx.doi.org/10.1007/82_2015_433

Ejemplares similares

HIV-1 Protease and Reverse Transcriptase Control the Architecture of Their Nucleocapsid Partner
por: Mirambeau, Gilles, et al.
Publicado: (2007)

Inhibitory Effect of Lithospermic Acid on the HIV-1 Nucleocapsid Protein
por: Mori, Mattia, et al.
Publicado: (2020)

RNA remarkably promotes HIV-1 protease fast turnover for NCp15 processing in mild acidic conditions leading to condensation of HIV-1 nucleocapsid
por: Lyonnais, Sebastien, et al.
Publicado: (2013)

The HIV-1 Nucleocapsid Regulates Its Own Condensation by Phase-Separated Activity-Enhancing Sequestration of the Viral Protease during Maturation
por: Lyonnais, Sébastien, et al.
Publicado: (2021)

FRET-based assay to screen inhibitors of HIV-1 reverse transcriptase and nucleocapsid protein
por: Sharma, Kamal K., et al.
Publicado: (2016)

Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1
por: Ku, Therese, et al.
Publicado: (2019)

Retrospective on the all-in-one retroviral nucleocapsid protein
por: Darlix, Jean-Luc, et al.
Publicado: (2014)

Sensing peptide–oligonucleotide interactions by a two-color fluorescence label: application to the HIV-1 nucleocapsid protein
por: Shvadchak, Volodymyr V., et al.
Publicado: (2009)

Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis
por: Mouhand, Assia, et al.
Publicado: (2018)

6(th )International Symposium on Retroviral Nucleocapsid
por: Berkhout, Ben, et al.
Publicado: (2008)

The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA
por: Jiang, Kai, et al.
Publicado: (2021)

Comparative nucleic acid chaperone properties of the nucleocapsid protein NCp7 and Tat protein of HIV-1
por: Godet, Julien, et al.
Publicado: (2012)

Insights into the mechanisms of RNA secondary structure destabilization by the HIV-1 nucleocapsid protein
por: Belfetmi, Anissa, et al.
Publicado: (2016)

Intrinsic Nucleic Acid Dynamics Modulates HIV-1 Nucleocapsid Protein Binding to Its Targets
por: Bazzi, Ali, et al.
Publicado: (2012)

How HIV-1 Gag Manipulates Its Host Cell Proteins: A Focus on Interactors of the Nucleocapsid Domain
por: Klingler, Jéromine, et al.
Publicado: (2020)

Investigating the Cellular Distribution and Interactions of HIV-1 Nucleocapsid Protein by Quantitative Fluorescence Microscopy
por: Anton, Halina, et al.
Publicado: (2015)

Structural determinants of TAR RNA-DNA annealing in the absence and presence of HIV-1 nucleocapsid protein
por: Kanevsky, Igor, et al.
Publicado: (2011)

Probing dynamics of HIV-1 nucleocapsid protein/target hexanucleotide complexes by 2-aminopurine
por: Avilov, S. V., et al.
Publicado: (2008)

Site-selective probing of cTAR destabilization highlights the necessary plasticity of the HIV-1 nucleocapsid protein to chaperone the first strand transfer
por: Godet, Julien, et al.
Publicado: (2013)

Dynamics of Linker Residues Modulate the Nucleic Acid Binding Properties of the HIV-1 Nucleocapsid Protein Zinc Fingers
por: Zargarian, Loussiné, et al.
Publicado: (2014)

Structural insights into the cTAR DNA recognition by the HIV-1 nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC
por: Bazzi, Ali, et al.
Publicado: (2011)

A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions
por: Vercruysse, Thomas, et al.
Publicado: (2012)

Specific implications of the HIV-1 nucleocapsid zinc fingers in the annealing of the primer binding site complementary sequences during the obligatory plus strand transfer
por: Godet, Julien, et al.
Publicado: (2011)

Group Normative Propensities, Societal Positioning, and Childbearing: Ethno‑linguistic Variation in Completed and Desired Fertility in Transitional Central Asia
por: Agadjanian, Victor, et al.
Publicado: (2022)

Interactions of HIV-1 Capsid with Host Factors and Their Implications for Developing Novel Therapeutics
por: Zhuang, Shentian, et al.
Publicado: (2021)

Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors
por: Sosic, Alice, et al.
Publicado: (2015)

Fertility Desires among Women Living with HIV
por: Jones, Deborah Lynne, et al.
Publicado: (2016)

Creating a sustainable and desirable future : insights from 45 global thought leaders
Publicado: (2014)

Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides
por: Fisher, Robert J., et al.
Publicado: (2006)

Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides
por: Fisher, Robert J., et al.
Publicado: (2006)

Structure of the Nucleocapsid Protein of Porcine Reproductive and Respiratory Syndrome Virus
por: Doan, Danny N.P, et al.
Publicado: (2003)

Required and desired: breakthroughs for future-proofing mineral and metal extraction
por: Clausen, Elisabeth, et al.
Publicado: (2022)

Meta-analyses of fertility desires of people living with HIV
por: Berhan, Yifru, et al.
Publicado: (2013)

Desired future conditions for Piñon-Juniper Ecosystems : august 8-12, 1994, Flagstaff, Arizona /
Publicado: (1995)

Politics and Research: a desirable and essential dialogue
por: Bifulco, Maurizio
Publicado: (2014)

Virtual Screening for HIV Protease Inhibitors: A Comparison of AutoDock 4 and Vina
por: Chang, Max W., et al.
Publicado: (2010)

Foreword to the Virus Research Special issue on “Retroviral RNA, protein co-factors and chaperones”
por: Mirambeau, Gilles, et al.
Publicado: (2012)

Unfolding of DNA quadruplexes induced by HIV-1 nucleocapsid protein
por: Kankia, Besik I., et al.
Publicado: (2005)

Inference of Epistatic Effects Leading to Entrenchment and Drug Resistance in HIV-1 Protease
por: Flynn, William F., et al.
Publicado: (2017)

HIV-1 nucleocapsid and ESCRT-component Tsg101 interplay prevents HIV from turning into a DNA-containing virus
por: Chamontin, Célia, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_p3bplakvr8mcf74v551t5h7kqn