Acute Liver Failure in Children

“Acute liver failure” (ALF) and “fulminant liver failure” are terms used interchangeably to describe severe and sudden onset of liver cell dysfunction leading on to synthetic and detoxification failure across all age groups. Considerable variations exist between ALF in children and adults, in terms...

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Detalles Bibliográficos
Autores principales: Shanmugam, Naresh, Dhawan, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122201/
http://dx.doi.org/10.1007/978-3-319-96400-3_8
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author Shanmugam, Naresh
Dhawan, Anil
author_facet Shanmugam, Naresh
Dhawan, Anil
author_sort Shanmugam, Naresh
collection PubMed
description “Acute liver failure” (ALF) and “fulminant liver failure” are terms used interchangeably to describe severe and sudden onset of liver cell dysfunction leading on to synthetic and detoxification failure across all age groups. Considerable variations exist between ALF in children and adults, in terms of aetiology and prognosis. Encephalopathy is not essential to make a diagnosis of ALF in children but when present has a bad prognosis. Early recognition of ALF and initiation of supportive management improve the outcome. Liver transplantation remains the only definitive treatment when supportive medical management fails.
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spelling pubmed-71222012020-04-06 Acute Liver Failure in Children Shanmugam, Naresh Dhawan, Anil Pediatric Hepatology and Liver Transplantation Article “Acute liver failure” (ALF) and “fulminant liver failure” are terms used interchangeably to describe severe and sudden onset of liver cell dysfunction leading on to synthetic and detoxification failure across all age groups. Considerable variations exist between ALF in children and adults, in terms of aetiology and prognosis. Encephalopathy is not essential to make a diagnosis of ALF in children but when present has a bad prognosis. Early recognition of ALF and initiation of supportive management improve the outcome. Liver transplantation remains the only definitive treatment when supportive medical management fails. 2018-10-16 /pmc/articles/PMC7122201/ http://dx.doi.org/10.1007/978-3-319-96400-3_8 Text en © Springer Nature Switzerland AG 2019 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Shanmugam, Naresh
Dhawan, Anil
Acute Liver Failure in Children
title Acute Liver Failure in Children
title_full Acute Liver Failure in Children
title_fullStr Acute Liver Failure in Children
title_full_unstemmed Acute Liver Failure in Children
title_short Acute Liver Failure in Children
title_sort acute liver failure in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122201/
http://dx.doi.org/10.1007/978-3-319-96400-3_8
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