TLR Signaling and Tumour-Associated Macrophages

The role that Toll-like receptor (TLR) signaling may have in stimulating macrophages to become tumor promoting is not yet clearly defined. However, given the role macrophages play in restoring tissue homeostasis such as in the tissue repair response, it is likely that tumor-induced TLR signaling pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Colegio, Oscar R., Medzhitov, Ruslan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122207/
http://dx.doi.org/10.1007/978-1-4614-0662-4_9
_version_ 1783515367437500416
author Colegio, Oscar R.
Medzhitov, Ruslan
author_facet Colegio, Oscar R.
Medzhitov, Ruslan
author_sort Colegio, Oscar R.
collection PubMed
description The role that Toll-like receptor (TLR) signaling may have in stimulating macrophages to become tumor promoting is not yet clearly defined. However, given the role macrophages play in restoring tissue homeostasis such as in the tissue repair response, it is likely that tumor-induced TLR signaling provides macrophages with signals of persistent injury. In this chapter, we review the molecular determinants of TLR signaling, the role TLR signaling plays in infection, wound healing, and tumorigenesis and discuss how TLR signaling in tumor-associated macrophages may result in tumor progression.
format Online
Article
Text
id pubmed-7122207
institution National Center for Biotechnology Information
language English
publishDate 2011
record_format MEDLINE/PubMed
spelling pubmed-71222072020-04-06 TLR Signaling and Tumour-Associated Macrophages Colegio, Oscar R. Medzhitov, Ruslan Tumour-Associated Macrophages Article The role that Toll-like receptor (TLR) signaling may have in stimulating macrophages to become tumor promoting is not yet clearly defined. However, given the role macrophages play in restoring tissue homeostasis such as in the tissue repair response, it is likely that tumor-induced TLR signaling provides macrophages with signals of persistent injury. In this chapter, we review the molecular determinants of TLR signaling, the role TLR signaling plays in infection, wound healing, and tumorigenesis and discuss how TLR signaling in tumor-associated macrophages may result in tumor progression. 2011-06-14 /pmc/articles/PMC7122207/ http://dx.doi.org/10.1007/978-1-4614-0662-4_9 Text en © Springer Science+Business Media, LLC 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Colegio, Oscar R.
Medzhitov, Ruslan
TLR Signaling and Tumour-Associated Macrophages
title TLR Signaling and Tumour-Associated Macrophages
title_full TLR Signaling and Tumour-Associated Macrophages
title_fullStr TLR Signaling and Tumour-Associated Macrophages
title_full_unstemmed TLR Signaling and Tumour-Associated Macrophages
title_short TLR Signaling and Tumour-Associated Macrophages
title_sort tlr signaling and tumour-associated macrophages
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122207/
http://dx.doi.org/10.1007/978-1-4614-0662-4_9
work_keys_str_mv AT colegiooscarr tlrsignalingandtumourassociatedmacrophages
AT medzhitovruslan tlrsignalingandtumourassociatedmacrophages

Ejemplares similares