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The Role of Angiotensin–(1-7) in Cancer
The rationale to investigate the role of angiotensin-(1-7) [Ang-(1-7)] in cancer relies on the fact that the heptapeptide inhibits the growth of several cell lines. The first studies showed that Ang-(1-7) accelerated hematopoietic recovery in the peripheral blood and bone marrow after chemotherapy a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122233/ http://dx.doi.org/10.1007/978-3-030-22696-1_14 |
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author | Simões e Silva, Ana Cristina Sampaio, Walkyria O. |
author_facet | Simões e Silva, Ana Cristina Sampaio, Walkyria O. |
author_sort | Simões e Silva, Ana Cristina |
collection | PubMed |
description | The rationale to investigate the role of angiotensin-(1-7) [Ang-(1-7)] in cancer relies on the fact that the heptapeptide inhibits the growth of several cell lines. The first studies showed that Ang-(1-7) accelerated hematopoietic recovery in the peripheral blood and bone marrow after chemotherapy and inhibits lung cancer cell growth through the activation of Mas receptor. In this chapter, we summarize studies on the role of Ang-(1-7) in different types of cancer, especially lung, breast, prostate, hepatocellular cancers and in gliobalstoma multiforme (GBM). The antitumor effect of Ang-(1-7) was due to reduction of angiogenesis, cancer-associated fibrosis, osteoclastogenesis, tumor-induced inflammation, and metastasis as well as inhibition of cancer cell growth and proliferation. In clinical trials, Ang-(1-7) was well tolerated with limited toxic or quality-of-life side effects and showed clinical benefit in cancer patients with solid tumors. Further clinical trials are needed to confirm safety, to determine doses and clinical indications. |
format | Online Article Text |
id | pubmed-7122233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71222332020-04-06 The Role of Angiotensin–(1-7) in Cancer Simões e Silva, Ana Cristina Sampaio, Walkyria O. Angiotensin-(1-7) Article The rationale to investigate the role of angiotensin-(1-7) [Ang-(1-7)] in cancer relies on the fact that the heptapeptide inhibits the growth of several cell lines. The first studies showed that Ang-(1-7) accelerated hematopoietic recovery in the peripheral blood and bone marrow after chemotherapy and inhibits lung cancer cell growth through the activation of Mas receptor. In this chapter, we summarize studies on the role of Ang-(1-7) in different types of cancer, especially lung, breast, prostate, hepatocellular cancers and in gliobalstoma multiforme (GBM). The antitumor effect of Ang-(1-7) was due to reduction of angiogenesis, cancer-associated fibrosis, osteoclastogenesis, tumor-induced inflammation, and metastasis as well as inhibition of cancer cell growth and proliferation. In clinical trials, Ang-(1-7) was well tolerated with limited toxic or quality-of-life side effects and showed clinical benefit in cancer patients with solid tumors. Further clinical trials are needed to confirm safety, to determine doses and clinical indications. 2019-05-22 /pmc/articles/PMC7122233/ http://dx.doi.org/10.1007/978-3-030-22696-1_14 Text en © Springer Nature Switzerland AG 2019 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Simões e Silva, Ana Cristina Sampaio, Walkyria O. The Role of Angiotensin–(1-7) in Cancer |
title | The Role of Angiotensin–(1-7) in Cancer |
title_full | The Role of Angiotensin–(1-7) in Cancer |
title_fullStr | The Role of Angiotensin–(1-7) in Cancer |
title_full_unstemmed | The Role of Angiotensin–(1-7) in Cancer |
title_short | The Role of Angiotensin–(1-7) in Cancer |
title_sort | role of angiotensin–(1-7) in cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122233/ http://dx.doi.org/10.1007/978-3-030-22696-1_14 |
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