Cargando…
Viral-Bacterial Interactions in Childhood Respiratory Tract Infections
Acute respiratory infection (ARI) is an important cause of childhood morbidity and mortality worldwide. ARIs are caused primarily by viruses and bacteria that are often co-detected in respiratory specimens. Although viral-bacterial co-infections are frequently reported in children with ARI, their cl...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122469/ http://dx.doi.org/10.1007/978-3-319-54033-7_8 |
_version_ | 1783515424422363136 |
---|---|
author | Annamalay, Alicia Le Souëf, Peter |
author_facet | Annamalay, Alicia Le Souëf, Peter |
author_sort | Annamalay, Alicia |
collection | PubMed |
description | Acute respiratory infection (ARI) is an important cause of childhood morbidity and mortality worldwide. ARIs are caused primarily by viruses and bacteria that are often co-detected in respiratory specimens. Although viral-bacterial co-infections are frequently reported in children with ARI, their clinical significance and the mechanisms leading to ARI are not well understood. The respiratory tract is a reservoir of a diverse community of microorganisms, including both commensals and potential pathogens and there is growing evidence that the interactions between viruses and bacteria play a key role in the development of ARI. A better understanding of the interactions between viruses and bacteria in the respiratory tract may enhance insight into the pathogenesis of ARI, and potentially reveal new prevention and treatment strategies. This chapter summarizes the current knowledge on viruses, bacteria and viral-bacterial interactions in childhood ARI and the possible mechanisms by which these interactions may lead to disease. |
format | Online Article Text |
id | pubmed-7122469 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71224692020-04-06 Viral-Bacterial Interactions in Childhood Respiratory Tract Infections Annamalay, Alicia Le Souëf, Peter Viral Infections in Children, Volume I Article Acute respiratory infection (ARI) is an important cause of childhood morbidity and mortality worldwide. ARIs are caused primarily by viruses and bacteria that are often co-detected in respiratory specimens. Although viral-bacterial co-infections are frequently reported in children with ARI, their clinical significance and the mechanisms leading to ARI are not well understood. The respiratory tract is a reservoir of a diverse community of microorganisms, including both commensals and potential pathogens and there is growing evidence that the interactions between viruses and bacteria play a key role in the development of ARI. A better understanding of the interactions between viruses and bacteria in the respiratory tract may enhance insight into the pathogenesis of ARI, and potentially reveal new prevention and treatment strategies. This chapter summarizes the current knowledge on viruses, bacteria and viral-bacterial interactions in childhood ARI and the possible mechanisms by which these interactions may lead to disease. 2017-05-05 /pmc/articles/PMC7122469/ http://dx.doi.org/10.1007/978-3-319-54033-7_8 Text en © Springer International Publishing AG 2017 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Annamalay, Alicia Le Souëf, Peter Viral-Bacterial Interactions in Childhood Respiratory Tract Infections |
title | Viral-Bacterial Interactions in Childhood Respiratory Tract Infections |
title_full | Viral-Bacterial Interactions in Childhood Respiratory Tract Infections |
title_fullStr | Viral-Bacterial Interactions in Childhood Respiratory Tract Infections |
title_full_unstemmed | Viral-Bacterial Interactions in Childhood Respiratory Tract Infections |
title_short | Viral-Bacterial Interactions in Childhood Respiratory Tract Infections |
title_sort | viral-bacterial interactions in childhood respiratory tract infections |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122469/ http://dx.doi.org/10.1007/978-3-319-54033-7_8 |
work_keys_str_mv | AT annamalayalicia viralbacterialinteractionsinchildhoodrespiratorytractinfections AT lesouefpeter viralbacterialinteractionsinchildhoodrespiratorytractinfections |