The Role of T Cell Epitopes in Coronavirus Infection

Multiple MHV-specific CD4 and CD8 T cell epitopes have been identified in C57Bl/6 and BALB/c mice. In particular, at least two CD8 T cell epitopes are recognized in C57Bl/6 mice. In one model of MHV persistence, mutations are detected in the immunodominant CD8 T cell epitope recognized in this strai...

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Detalles Bibliográficos
Autores principales: Kim, Taeg S., Perlman, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122487/
http://dx.doi.org/10.1007/0-387-25518-4_42
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author Kim, Taeg S.
Perlman, Stanley
author_facet Kim, Taeg S.
Perlman, Stanley
author_sort Kim, Taeg S.
collection PubMed
description Multiple MHV-specific CD4 and CD8 T cell epitopes have been identified in C57Bl/6 and BALB/c mice. In particular, at least two CD8 T cell epitopes are recognized in C57Bl/6 mice. In one model of MHV persistence, mutations are detected in the immunodominant CD8 T cell epitope recognized in this strain. These mutations contribute to virus persistence and to the development of more severe clinical disease.
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spelling pubmed-71224872020-04-06 The Role of T Cell Epitopes in Coronavirus Infection Kim, Taeg S. Perlman, Stanley Experimental Models of Multiple Sclerosis Article Multiple MHV-specific CD4 and CD8 T cell epitopes have been identified in C57Bl/6 and BALB/c mice. In particular, at least two CD8 T cell epitopes are recognized in C57Bl/6 mice. In one model of MHV persistence, mutations are detected in the immunodominant CD8 T cell epitope recognized in this strain. These mutations contribute to virus persistence and to the development of more severe clinical disease. 2005 /pmc/articles/PMC7122487/ http://dx.doi.org/10.1007/0-387-25518-4_42 Text en © Springer Science+Business Media, Inc. 2005 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Kim, Taeg S.
Perlman, Stanley
The Role of T Cell Epitopes in Coronavirus Infection
title The Role of T Cell Epitopes in Coronavirus Infection
title_full The Role of T Cell Epitopes in Coronavirus Infection
title_fullStr The Role of T Cell Epitopes in Coronavirus Infection
title_full_unstemmed The Role of T Cell Epitopes in Coronavirus Infection
title_short The Role of T Cell Epitopes in Coronavirus Infection
title_sort role of t cell epitopes in coronavirus infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122487/
http://dx.doi.org/10.1007/0-387-25518-4_42
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