Heat Shock Proteins in Inflammation

HSPs are important mediators of a number of key intracellular reactions. Of importance to the care of the critically ill are their involvement in protein repair and tertiary structure. HSP70 is known to modulate inflammation and apoptosis. In models of acute lung injury and ARDS, over-expression of...

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Detalles Bibliográficos
Autores principales: Bromberg, Z., Weiss, Y. G., Deutschman, C. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122530/
http://dx.doi.org/10.1007/3-540-30328-6_8
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author Bromberg, Z.
Weiss, Y. G.
Deutschman, C. S.
author_facet Bromberg, Z.
Weiss, Y. G.
Deutschman, C. S.
author_sort Bromberg, Z.
collection PubMed
description HSPs are important mediators of a number of key intracellular reactions. Of importance to the care of the critically ill are their involvement in protein repair and tertiary structure. HSP70 is known to modulate inflammation and apoptosis. In models of acute lung injury and ARDS, over-expression of HSP70 improves outcome, ameliorates lung injury and attenuates inflammation. The involvement of HSP70 in other aspects of lung injury and in other components of MODS is under investigation.
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spelling pubmed-71225302020-04-06 Heat Shock Proteins in Inflammation Bromberg, Z. Weiss, Y. G. Deutschman, C. S. Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery Article HSPs are important mediators of a number of key intracellular reactions. Of importance to the care of the critically ill are their involvement in protein repair and tertiary structure. HSP70 is known to modulate inflammation and apoptosis. In models of acute lung injury and ARDS, over-expression of HSP70 improves outcome, ameliorates lung injury and attenuates inflammation. The involvement of HSP70 in other aspects of lung injury and in other components of MODS is under investigation. 2007 /pmc/articles/PMC7122530/ http://dx.doi.org/10.1007/3-540-30328-6_8 Text en © Springer-Verlag Berlin Heidelberg 2007 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Bromberg, Z.
Weiss, Y. G.
Deutschman, C. S.
Heat Shock Proteins in Inflammation
title Heat Shock Proteins in Inflammation
title_full Heat Shock Proteins in Inflammation
title_fullStr Heat Shock Proteins in Inflammation
title_full_unstemmed Heat Shock Proteins in Inflammation
title_short Heat Shock Proteins in Inflammation
title_sort heat shock proteins in inflammation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122530/
http://dx.doi.org/10.1007/3-540-30328-6_8
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