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The Role of Metalloproteinases in Corona Virus Infection

Infection with neurotropic strains of mouse hepatitis virus (MHV) results in rapid leukocyte infiltration into the central nervous system (CNS). The inflammatory response controls virus replication but fails to mediate sterile clearance. The persistence of viral RNA and inflammatory cells within the...

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Autores principales: Marten, Norman W., Zhou, Jiehao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122609/
http://dx.doi.org/10.1007/0-387-25518-4_48
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author Marten, Norman W.
Zhou, Jiehao
author_facet Marten, Norman W.
Zhou, Jiehao
author_sort Marten, Norman W.
collection PubMed
description Infection with neurotropic strains of mouse hepatitis virus (MHV) results in rapid leukocyte infiltration into the central nervous system (CNS). The inflammatory response controls virus replication but fails to mediate sterile clearance. The persistence of viral RNA and inflammatory cells within the CNS is associated with the development of ongoing demyelination. Matrix metalloproteinases (MMPs) are a family of proteases involved in degradation of the extracellular matrix (ECM). During inflammatory responses MMPs are thought to play a significant role in breaking down the basement membrane surrounding blood vessels as well as parenchymal ECM thereby facilitating leukocyte infiltration. MMPs have also been associated with activation of chemokines and perhaps more significantly the degradation of myelin proteins and generation of autoantigens. Recent examination of MMP expression during MHV infection suggests that MMP-3, -9 and -12 are involved in the inflammatory response. The proinflammatory effects of these MMPs are likely tempered by induction of tissue inhibiter of metalloproteinase-1 expression.
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spelling pubmed-71226092020-04-06 The Role of Metalloproteinases in Corona Virus Infection Marten, Norman W. Zhou, Jiehao Experimental Models of Multiple Sclerosis Article Infection with neurotropic strains of mouse hepatitis virus (MHV) results in rapid leukocyte infiltration into the central nervous system (CNS). The inflammatory response controls virus replication but fails to mediate sterile clearance. The persistence of viral RNA and inflammatory cells within the CNS is associated with the development of ongoing demyelination. Matrix metalloproteinases (MMPs) are a family of proteases involved in degradation of the extracellular matrix (ECM). During inflammatory responses MMPs are thought to play a significant role in breaking down the basement membrane surrounding blood vessels as well as parenchymal ECM thereby facilitating leukocyte infiltration. MMPs have also been associated with activation of chemokines and perhaps more significantly the degradation of myelin proteins and generation of autoantigens. Recent examination of MMP expression during MHV infection suggests that MMP-3, -9 and -12 are involved in the inflammatory response. The proinflammatory effects of these MMPs are likely tempered by induction of tissue inhibiter of metalloproteinase-1 expression. 2005 /pmc/articles/PMC7122609/ http://dx.doi.org/10.1007/0-387-25518-4_48 Text en © Springer Science+Business Media, Inc. 2005 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Marten, Norman W.
Zhou, Jiehao
The Role of Metalloproteinases in Corona Virus Infection
title The Role of Metalloproteinases in Corona Virus Infection
title_full The Role of Metalloproteinases in Corona Virus Infection
title_fullStr The Role of Metalloproteinases in Corona Virus Infection
title_full_unstemmed The Role of Metalloproteinases in Corona Virus Infection
title_short The Role of Metalloproteinases in Corona Virus Infection
title_sort role of metalloproteinases in corona virus infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7122609/
http://dx.doi.org/10.1007/0-387-25518-4_48
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